Edited by: Thomas Bieber
Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy
Version of Record online: 20 NOV 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 69, Issue 2, pages 265–268, February 2014
How to Cite
Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy. Allergy 2014; 69: 265–268., , , , , , .
- Issue online: 27 JAN 2014
- Version of Record online: 20 NOV 2013
- Manuscript Accepted: 7 OCT 2013
- food allergy;
- tree nut allergy;
A relationship between serum basal tryptase (sBT) levels, anaphylactic reactions, and clonal mast cell diseases was shown recently in adults with venom allergy, but the relationship between sBT levels and IgE-mediated food allergy and anaphylaxis is not known. In this study, children with food allergy (FA; n = 167) were analyzed in two groups according to the presence (FA+/A+; n = 79) or absence of anaphylaxis (FA+/A−; n = 88) and were compared with a control group (n = 113). Median sBT values in FA+/A+, FA+/A−, and control groups were 4.0 ng/ml (2.8–5.8), 3.6 (2.3–4.5), and 3.3 (2.4–4.4), respectively (P = 0.022). sBT measurements higher than the cutoff values of 5.7 and 14.5 were associated with 50% and 90% predicted probabilities, respectively, of moderate to severe anaphylaxis. Children with tree nuts/peanut allergies had significantly higher levels of sBT than children with milk and egg allergy (P = 0.022). Results suggest that sBT levels may predict moderate to severe anaphylaxis in children with food allergy, which may follow a particular pattern according to the food allergy phenotype.