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Data S1. Detailed description of study populations and investigated phenotypes; and Details on polymorphism selection for genotyping.

Figure S1. Selection process of polymorphisms from FCER2 gene region.

Figure S2. Schematic representation of FCER2 gene region with location of genotyped polymorphisms (rs numbers), tagging bins (in brackets), and pair wise linkage disequilibrium (r2).

Table S1. Descriptive statistics of MAGICS and ISAAC populations.

Table S2. Associations of FCER2 polymorphisms with total serum IgE levels.

Table S3. Associations of FCER2 polymorphisms with total serum IgE levels (in the cross-sectional ISAAC II cohort).

Table S4. Interaction effects of FCER1A rs2427837 and FCER2 rs3760687 on total serum IgE levels.

Table S5. Associations of FCER2 polymorphisms with asthma and its subphenotypes.

Table S6. Associations of FCER2 polymorphisms with atopic sensitization, allergic rhinitis and atopic dermatitis.

Table S7.In silico analysis of putative functional effects of single nucleotide polymorphisms (SNPs) associated with IgE levels.

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