New approaches to the prevention of childhood atopic dermatitis

Authors

  • C. Flohr,

    Corresponding author
    1. Departments of Paediatric Dermatology & Children's Allergies, St John's Institute of Dermatology, Guy's and St Thomas' Hospitals NHS Foundation Trust and King's College, London, UK
    • Correspondence

      Dr. Carsten Flohr, Departments of Paediatric Dermatology & Children's Allergies, St John's Institute of Dermatology, St Thomas' Hospital and King's College London, London SE1 7EH, UK.

      Tel.: +44 (0)20 7188 7188, ext 51601

      Fax: +44 (0)20 7188 9782

      E-mail: carsten.flohr@kcl.ac.uk

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  • J. Mann

    1. Department of Dermatology, Medway NHS Foundation Trust, Medway Maritime Hospital, Gillingham, Kent, UK
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  • Edited by: Stephan Weidinger

Abstract

There has been a steep rise in the burden of atopic dermatitis (AD), and up to 20% of children in developed countries now suffer of the disease. At present, treatment at best achieves symptom control rather than cure, and there is a strong need to identify new methods of disease prevention. While earlier approaches focused on allergen avoidance strategies, there has been a clear shift towards attempts to induce tolerance and enhancement of skin barrier function, as skin barrier breakdown plays an important role in AD development. This article reviews the latest developments in the prevention of AD.

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