These authors contributed equally to this study.
Aeroallergen and food IgE sensitization and local and systemic inflammation in asthma
Article first published online: 7 JAN 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 69, Issue 3, pages 380–387, March 2014
How to Cite
Aeroallergen and food IgE sensitization and local and systemic inflammation in asthma. Allergy 2014; 69: 380–387., , , , , .
Edited by: Douglas Robinson
- Issue published online: 18 FEB 2014
- Article first published online: 7 JAN 2014
- Manuscript Accepted: 8 NOV 2013
- Swedish Governmental Agency for Innovation Systems. Grant Number: 2007-00084
- Bror Hjerpstedts Foundation
- airway responsiveness;
- blood eosinophilic count;
- exhaled nitric oxide;
- food allergens
We recently reported an independent association between IgE sensitization to food allergens and increased airway inflammation, assessed by fraction of exhaled nitric oxide (FeNO), in a population-based study (J Allergy Clin Immunol, 130, 2012, 397). Similar studies have not been performed in populations with asthma. The aim of the present study was to investigate the allergic sensitization profile in asthmatics and examine FeNO, airway responsiveness and blood eosinophilia in relation to type and degree of IgE sensitization.
FeNO, airway responsiveness, blood eosinophil count (B-Eos) and IgE sensitization to food allergens and aeroallergens were determined in 408 subjects with asthma, aged 10–34 years.
Asthmatics had higher prevalence of IgE sensitization against all allergens than controls (P < 0.001). Mite, pollen, furry animal, mould and food sensitizations were each associated with increased FeNO, airway responsiveness and B-Eos in asthmatics. IgE sensitization to mould, furry animals and food allergens was independently related to FeNO (all P < 0.05) after adjustment for age, sex, height, smoking history and medication. IgE sensitization to mould (P < 0.001) and furry animals (P = 0.02) was related to airway responsiveness in a similar model. Finally, IgE sensitization to mould (P = 0.001), furry animals (P < 0.001) and food allergens (P < 0.001) was independently related to B-Eos.
Independent effects of IgE sensitization to aeroallergens (furry animals and mould) and food allergens were found on both local and systemic markers of inflammation in asthma. The finding regarding food IgE sensitization is novel, and a clinical implication might be that even food sensitization must be assessed to fully understand inflammation patterns in asthma.