Presented in part at the EuroSIVA Annual Scientific Meeting, Vienna, May 2005.
The effect of propofol on patient reaction time and its relationship with loss of verbal contact before induction of anaesthesia*
Article first published online: 15 NOV 2012
Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland
Volume 68, Issue 2, pages 148–153, February 2013
How to Cite
Anderson, K. J., Allam, S., Chapman, R. and Kenny, G. N. C. (2013), The effect of propofol on patient reaction time and its relationship with loss of verbal contact before induction of anaesthesia. Anaesthesia, 68: 148–153. doi: 10.1111/anae.12035
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- Issue published online: 9 JAN 2013
- Article first published online: 15 NOV 2012
- Accepted: 9 September 2012
Increasing the calculated plasma concentration of propofol has been shown to increase choice reaction time and visual and auditory response times. We studied the relationship of reaction to a vibrating handset as the effect-site target-controlled propofol concentration was incrementally increased in 20 patients during sedation, before induction of general anaesthesia. The reaction time increased, initially slowly and then more rapidly, as the calculated effect-site concentration of propofol increased, until the reaction to the vibrating handset was lost at a mean (SD) propofol effect-site concentration of 2.0 (0.6) μg.ml−1. The loss of response to verbal contact occurred at a propofol effect-site concentration of 2.4 (0.5) μg.ml−1. Reaction time may be of use clinically to warn of impending loss of verbal contact.