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Inflammatory mechanisms of ventilator-induced lung injury: a time to stop and think?
Article first published online: 22 NOV 2012
Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland
Volume 68, Issue 2, pages 175–178, February 2013
How to Cite
Wilson, M. R. and Takata, M. (2013), Inflammatory mechanisms of ventilator-induced lung injury: a time to stop and think?. Anaesthesia, 68: 175–178. doi: 10.1111/anae.12085
Editorial note: ‘Science Letters’ is an occasional feature in which we offer researchers working in basic science, or in a very specific area of biomedical science, an opportunity to explain their work to a wide clinical anaesthetist readership. We challenge them to outline the nature and clinical implications of their work, and its potential and actual relevance to anaesthesia, in a way that engages and enthuses readers to adapt their own, clinical researches so as to take better account of this science. Researchers willing to take up the challenge are invited to contact the Editor-in-Chief.
- Issue published online: 9 JAN 2013
- Article first published online: 22 NOV 2012
- Manuscript Accepted: 15 OCT 2012
Ventilator-induced lung injury (VILI) is the phenomenon by which mechanical ventilation exacerbates lung injury in critically ill patients. It is particularly relevant for those suffering from acute respiratory distress syndrome, in which the iatrogenic injury caused by VILI contributes to their high mortality. The innate immune system is widely accepted to play an important role during VILI. However, it is our belief that the identification of inflammatory mediators that are crucial during VILI, and thus may make useful therapeutic targets, has become obscured by the wide variety of pre-clinical animal models of VILI reported in the literature. We aim here to summarise some of our work addressing this issue over the last 10 years, and thus, we hope, make interpretation of a convoluted field a little clearer.