Fluctuations of MS births and UV-light exposure
Article first published online: 12 SEP 2012
© 2012 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 127, Issue 5, pages 301–308, May 2013
How to Cite
Fluctuations of MS births and UV-light exposure. Acta Neurol Scand: DOI: 10.1111/ane.12007. © 2012 John Wiley & Sons A/S., , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
- Issue published online: 13 APR 2013
- Article first published online: 12 SEP 2012
- Manuscript Accepted: 13 AUG 2012
- European Commission. Grant Number: 018385-2
- multiple sclerosis;
- birth season;
- ultraviolet light
Patients with multiple sclerosis (MS) are more frequently born in spring when compared to autumn. Fluctuation of UV-light has been hypothesized to drive this phenomenon.
To assess the correlation between fluctuation of sunlight and birth season in persons with MS.
For this record-linkage study, we collected from the international MSBase and the Italian MS iMed-web databases the dates of birth of 11,415 patients with MS from 36 centres from 15 countries worldwide and compared these to dates of live-births from national registries. From all participating sites, we collected data on UV-light fluctuation and assessed its correlation with seasonal fluctuation in MS births.
Compared with the reference cohort, an increased proportion of persons with MS were born in spring and a decreased proportion in autumn (odds ratio (OR) to be born in spring versus autumn = 1.158, χ2 = 36.347, P < 0.001). There was no significantly increased fluctuation of MS births with increased quartile of ambient UV-light fluctuation (Ptrend = 0.086).
Seasonal fluctuation of MS births as found in this worldwide cohort of patients with MS did not correlate with variation in seasonal fluctuation of UV-light. Most likely, it results from a complex interplay between fluctuation of sunlight, behavioural factors, other environmental factors and (epi)genetic factors.