Long-term vagus nerve stimulation in children with focal epilepsy
Article first published online: 20 SEP 2012
© 2012 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 127, Issue 5, pages 316–322, May 2013
How to Cite
Long-term vagus nerve stimulation in children with focal epilepsy. Acta Neurol Scand: DOI: 10.1111/ane.12009. © 2012 John Wiley & Sons A/S., , , , , , .
- Issue published online: 13 APR 2013
- Article first published online: 20 SEP 2012
- Manuscript Accepted: 14 AUG 2012
- Central European Institute of Technology. Grant Number: CZ.1.05/1.1.00/02.0068
- child neurology;
- quality of life;
The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation.
Materials and methods
We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 ± 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation.
The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 ± 0.6 per year preoperatively and 0.3 ± 0.5 per year post-operatively (P < 0.0001). The mean number of days of urgent hospitalization per patient was 9.3 ± 6.1 per year preoperatively and 1.3 ± 1.8 per year post-operatively (P < 0.0001).
Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations.