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Clinical assessment and management of sleep disorders in multiple sclerosis: a literature review

Authors

  • H. M. B. Lunde,

    Corresponding author
    • Department of Neurology, The Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway
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  • B. Bjorvatn,

    1. Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway
    2. Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
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  • K.-M. Myhr,

    1. Department of Neurology, The Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway
    2. Department of Clinical Medicine, KG Jebsen Centre for MS-research, University of Bergen, Bergen, Norway
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  • L. Bø

    1. Department of Neurology, The Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway
    2. Department of Clinical Medicine, KG Jebsen Centre for MS-research, University of Bergen, Bergen, Norway
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H. M. B. Lunde, MD, the Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, 5021-Bergen, Norway

Tel.: +47 55975045

Fax: +47 55975164

e-mail: hmbl75@gmail.com

Abstract

The major sleep disorders are common in multiple sclerosis (MS) and are associated with significant morbidity. Despite this, the rate of recognition and management of these conditions are low. All types of sleep disorders are seen in patients with MS: insomnia, circadian rhythm sleep disorders, sleep-related movement disorders, sleep-related breathing disorders, hypersomnia (narcolepsy), and parasomnia (REM sleep behavior disorder; RBD). This literature review covers the prevalence, clinical features, and treatment of sleep disorders in MS. Based on clinical experience, the spectrum of symptoms associated with MS, and the current knowledge of MS pathophysiology, we have also enclosed proposed strategies for clinical assessment and investigation of sleep disorders in MS patients.

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