Incidence and predictors of post-stroke epilepsy
Article first published online: 7 FEB 2013
© 2013 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 127, Issue 6, pages 427–430, June 2013
How to Cite
Incidence and predictors of post-stroke epilepsy. Acta Neurol Scand 2013: DOI: 10.1111/ane.12070. © 2013 John Wiley & Sons A/S., , , , .
- Issue published online: 14 MAY 2013
- Article first published online: 7 FEB 2013
- Manuscript Accepted: 23 NOV 2012
- German Federal Ministry of Health. Grant Number: IIA5-2008-2508KEU305
- BMBF (Competence Net Stroke)
- Bavarian State Ministry of the Environment and Public Health
- Federal Ministry of Education and Research. Grant Number: CSB-01EO0801
- post-stroke epilepsy;
Background and aims
Stroke is the leading cause of seizures and epilepsy in the elderly. The aim of this study was to assess the incidence of post-stroke epilepsy (PSE) based on the revised epilepsy definition of the International League Against Epilepsy (ILAE) in a population-based study and to describe possible predictors.
Data from the prospective population-based Erlangen Stroke Project (ESPro) were collected to describe the frequency of PSE. Patients were followed up 3, 12, and 24 months after stroke. Stroke was diagnosed according to the WHO and PSE according to the new ILAE criteria. Multivariable analysis was performed to identify predictors of PSE including age, sex, stroke type, stroke severity, and comorbidities.
From 1998 to 2006, 1815 patients with first-ever stroke were included (55.7% women; mean age 72.7 years, SD 13). Patients with known (n = 52) or unknown (n = 331) prior-to-stroke epilepsy or no available information on post-stroke seizures (n = 412) were excluded. From the remaining 1020 patients, 84 (8.2%) developed PSE within 2 years after stroke. Univariate analysis demonstrated stroke severity (P < 0.001) and hypertension (P < 0.05) as predictors for PSE. In multivariable analysis, stroke severity remained the only independent predictor (P = 0.002).
Based on the revised ILAE definition of epilepsy, the incidence of PSE was high in the ESPro. The only independent predictor for PSE was stroke severity.