MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese
Article first published online: 15 MAR 2013
© 2013 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 128, Issue 2, pages 136–139, August 2013
How to Cite
MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese. Acta Neurol Scand 2013: 128: 136‒139. © 2013 John Wiley & Sons A/S., , , , , , , .
- Issue published online: 9 JUL 2013
- Article first published online: 15 MAR 2013
- Manuscript Accepted: 11 JAN 2013
- Duke–NUS Graduate Medical School
- Singapore Millennium Foundation
- National Medical Research Council
- West China Hospital of Sichuan University
- MCCC1/LAMP3 ;
- Parkinson's disease;
A recent large-scale replication and heterogeneity study reported the new described GWAS locus (MCCC1/LAMP3 rs11711441) was associated with a reduced risk of Parkinson disease (PD) in Asian and Caucasian populations. Its role is still unknown in a Han Chinese population from mainland China. We genotyped the rs11711441 variant to investigate the association with risk of PD.
Using a case–control methodology, a total of 1428 Han Chinese study subjects were genotyped. We also conducted further stratified analysis according to age at onset and compared the clinical characteristics of GA + AA subjects with GG subjects.
In this study, we confirmed that the A allele of MCCC1/LAMP3 (rs11711441) polymorphism reduces the risk to develop sporadic PD (P = 0.043). Additionally, subjects with GA + AA genotypes have a reduced risk compared to those with GG genotype (P = 0.022). The association was seen among the older age group (P = 0.014), but was not significant among the younger age group (P = 0.641). No significant differences were observed in gender, age at onset, and onset symptoms between GA + AA subjects and GG subjects.
Our study, the first from Mainland China demonstrates that MCCC1/LAMP3 (rs11711441) is associated with a lower risk of PD. Further studies in additional Chinese populations and other cohorts will be useful.