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MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese

Authors


R. Peng, Department of Neurology, West China Hospital, Sichuan University, Sichuan Province 610041, China

Tel.: +86 28 8542 3038

Fax: +86 28 8558 2944

e-mail: qrpeng@hotmail.com

Abstract

Background

A recent large-scale replication and heterogeneity study reported the new described GWAS locus (MCCC1/LAMP3 rs11711441) was associated with a reduced risk of Parkinson disease (PD) in Asian and Caucasian populations. Its role is still unknown in a Han Chinese population from mainland China. We genotyped the rs11711441 variant to investigate the association with risk of PD.

Methods

Using a case–control methodology, a total of 1428 Han Chinese study subjects were genotyped. We also conducted further stratified analysis according to age at onset and compared the clinical characteristics of GA + AA subjects with GG subjects.

Results

In this study, we confirmed that the A allele of MCCC1/LAMP3 (rs11711441) polymorphism reduces the risk to develop sporadic PD (= 0.043). Additionally, subjects with GA + AA genotypes have a reduced risk compared to those with GG genotype (= 0.022). The association was seen among the older age group (= 0.014), but was not significant among the younger age group (= 0.641). No significant differences were observed in gender, age at onset, and onset symptoms between GA + AA subjects and GG subjects.

Conclusion

Our study, the first from Mainland China demonstrates that MCCC1/LAMP3 (rs11711441) is associated with a lower risk of PD. Further studies in additional Chinese populations and other cohorts will be useful.

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