Statistical analysis was performed by Li-Nien Chien, Ph. D in School of Health Care Administration, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
Central nervous system infections and stroke – a population-based analysis
Article first published online: 1 APR 2013
© 2013 John Wiley & Sons A/S
Acta Neurologica Scandinavica
Volume 128, Issue 4, pages 241–248, October 2013
How to Cite
Central nervous system infections and stroke – a population-based analysis. Acta Neurol Scand 2013: 128: 241–248. © 2013 John Wiley & Sons A/S., , , .
- Issue published online: 10 SEP 2013
- Article first published online: 1 APR 2013
- Manuscript Accepted: 30 JAN 2013
- Ministry of Education Topnotch Stroke Research Center
- Department of Health Center of Excellence for Clinical Trial and Research in Neuroscience. Grant Numbers: DOH99-TD-B-111-003, DOH100-TD-B-111-003, DOH101-TD-B-111-003, DOH102-TD-B-111-003
- Dr. Chi-Chin Huang Stroke Research Center
- cerebrovascular diseases;
Chronic central nervous system (CNS) infections have been found to associate with cerebrovascular complications. Acute CNS infections are more common than chronic CNS infections, but whether they could increase the risk of vascular diseases has not been studied.
The study cohort comprised all adult patients with diagnoses of CNS infections from Taiwan National Health Insurance Research Database during 2000–2009 (n = 533). The comparison group were matched by age, sex, urbanization, diagnostic year, and vascular risk factors of cases (cases and controls = 1:5). Patients were tracked for at least 1 year. Kaplan–Meier analysis was used to compare the risk of stroke and acute myocardial infarction (AMI) after adjusting censoring subjects.
After adjusting the patients demographic characteristics and comorbidities, the risk of patients with CNS infections developing stroke was 2.75–3.44 times greater than their comparison group. More than 70% of the stroke events were occurring within 1 year after CNS infections. The risk of AMI was not found as we compared patients with and without CNS infections.
The population-based cohort study suggested that adult patients with CNS infections have higher risk to develop stroke but not AMI, and the risk is marked within a year after infections.