Mortality of subjects with alcohol-related seizures increased after alcohol cheapening
Version of Record online: 7 JUN 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Neurologica Scandinavica
Volume 129, Issue 1, pages 56–60, January 2014
How to Cite
Mortality of subjects with alcohol-related seizures increased after alcohol cheapening. Acta Neurol Scand 2014: 129: 56–60. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., , , , .
- Issue online: 3 DEC 2013
- Version of Record online: 7 JUN 2013
- Manuscript Accepted: 22 APR 2013
- alcohol price reduction;
- alcohol policy;
- mortality rate;
- head injury;
To investigate whether the reduction of alcohol prices in Finland (March 1, 2004) associated with an increase in mortality of subjects with alcohol-related seizures.
Patients and methods
All subjects with head trauma in Oulu University Hospital during 1999 (n = 827) were identified and thereafter followed up until death or the end of 2009. We used National Hospital Discharge Register, hospital charts, and death records from Official Cause-of-Death Statistics to identify seizure visits and alcohol-related deaths. Kaplan–Meier survival curves were used to characterize the effect of alcohol price reduction on risk of death. Cox proportional hazards model was used to identify independent predictors of death.
Twenty-five subjects had alcohol-related seizures before the alcohol price reduction. Their cumulative mortality rate was significantly higher (P = 0.015) than that of other head trauma subjects during the follow-up and it clearly increased after the price reduction. Age (HR 1.06 per year, 95% CI 1.05–1.07, P < 0.001), moderate-to-severe traumatic brain injury (HR 2.04 95% CI 1.37–3.04, P < 0.001), and alcohol-related seizure (HR 3.02, 95% CI 1.48–6.16, P = 0.002) were independent predictors of death after adjustment for confounding factors.
We conclude that the political decision to lower alcohol price associated with a significant increase in the mortality rate of subjects with alcohol-related seizures.