CRP gene polymorphism predicts post-stroke functional outcome in Han Chinese
Version of Record online: 23 AUG 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Neurologica Scandinavica
Volume 129, Issue 4, pages 263–268, April 2014
How to Cite
CRP gene polymorphism predicts post-stroke functional outcome in Han Chinese. Acta Neurol Scand 2014: 129: 263–268. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., , , , , .
- Issue online: 8 MAR 2014
- Version of Record online: 23 AUG 2013
- Manuscript Accepted: 30 JUL 2013
- China Postdoctoral Science Foundation. Grant Number: 2012M521699
- C-reactive protein;
- functional outcome;
- ischemic stroke;
Stroke is a major cause of long-term disability and morbidity worldwide. C-reactive protein (CRP), an inflammatory marker, has been reported to be an independent predictor of functional outcome after ischemic stroke (IS). Because several single nucleotide polymorphisms (SNPs) at the CRP locus have been linked with elevated CRP levels, we hypothesized that CRP genetic variation might be associated with functional disability in patients after first-ever IS.
A total of 1716 patients from western China with first-ever IS were genotyped for the CRP SNPs rs1130864 and rs1800947 using the ligation detection reaction method. Functional outcome was assessed 3 months after IS using the modified Rankin Scale. Then, we tested the association of CRP SNP genotypes with stroke outcome after adjusting for non-genetic factors.
Our data showed a significant association between the T allele of rs1130864 and poor functional outcome in IS patients. In addition, the presence of TT+CT genotypes of rs1130864 strongly predicted functional disability within the first 3 months, even after adjusting for potential confounders.
Our study indicates that SNP rs1130864 in the CRP gene is an independent predictor of 3-month functional outcome in patients with first-onset IS in a Han Chinese population. Further studies in different ethnic groups are needed to validate our findings.