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Word-level intelligibility after caudal zona incerta stimulation for Parkinson's disease

Authors

  • L. Johansson,

    1. Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, Umeå, Sweden
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    • These authors contributed equally to this work.
  • S. Möller,

    1. Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, Umeå, Sweden
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    • These authors contributed equally to this work.
  • K. Olofsson,

    1. Division of Otorhinolaryngology, Department of Clinical Sciences, Umeå University, Umeå, Sweden
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  • J. Linder,

    1. Division of Neurology, Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden
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  • E. Nordh,

    1. Division of Clinical Neurophysiology, Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden
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  • P. Blomstedt,

    1. Division of Neurosurgery, Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden
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  • J. van Doorn,

    1. Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, Umeå, Sweden
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  • F. Karlsson

    Corresponding author
    1. Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, Umeå, Sweden
    2. Department of Language Studies, Umeå University, Umeå, Sweden
    • F. Karlsson, Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, Sweden

      Tel.: +46 90 785 14 70

      Fax: +46 90 77 24 70

      e-mail: fredrik.karlsson@logopedi.umu.se

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Abstract

Objectives

To investigate the effect of caudal zona incerta-deep brain stimulation (cZi-DBS) on word-level speech intelligibility in patients with Parkinson's disease, under both an optimal listening condition and a simulated more naturalistic listening condition.

Materials and methods

Spoken single words were extracted from read samples collected from 10 bilaterally implanted patients with PD pre- and post-cZi-DBS. Intelligibility was assessed through a transcription task performed by 32 naive listeners under two listening conditions: (i) with low-amplitude conversational speech added as background and (ii) with no added background noise. The listeners′ responses were scored in terms of agreement with the intended words.

Results

Post-operatively, the total intelligibility score was significantly lower when cZi stimulation was switched on compared with off, for both listening conditions (with and without added background noise). Intelligibility was also significantly lower on stimulation compared with preoperative recordings, but only when assessed in the listening condition without background noise. The listening condition with added background noise resulted in significantly lower intelligibility scores compared with the no added noise condition for all stimulation conditions.

Conclusions

The results of this study indicate that cZi-DBS in patients with PD can be detrimental to word-level speech intelligibility.

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