Facial memory deficits in myotonic dystrophy type 1
Article first published online: 15 FEB 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Neurologica Scandinavica
How to Cite
Facial memory deficits in Myotonic dystrophy type 1. Acta Neurol Scand: DOI: 10.1111/ane.12228. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., , .
- Article first published online: 15 FEB 2014
- Manuscript Accepted: 14 JAN 2014
- West Swedish Muscle Foundation
- CTG repeats;
- facial memory;
- myotonic dystrophy type 1
To evaluate facial memory ability (FMA) in patients with myotonic dystrophy type 1 (DM1). We also explored the relationship between FMA and neuropsychological data, disease-related factors, and CTG repeat expansion size.
Materials and methods
Patients with DM1 (n = 33) and healthy subjects (n = 30) were tested with the faces task of the Rivermead Behavioural Memory Test – Extended version (RBMT-E) and an additional set of neuropsychological tests. Clinical data were collected, and CTG repeat size was quantified in blood lymphocytes.
Low results on the faces task were more common in patients with DM1 compared with healthy subjects (P < 0.05), with 36% of the patients showing a poor/impaired performance. DM1 patients with deficits in FMA performed significantly worse on tests measuring visual-construction ability and memory. Furthermore, these patients more often falsely recognised unknown faces as known. Deficits in FMA were not associated with any disease-related factor, including CTG repeat expansion size.
These findings revealed deficits in FMA in the DM1 group, which was associated with reduced construction- and visual memory ability.