MTHFR C677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese

Authors

  • Q. Liao,

    1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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  • N. N. Li,

    1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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  • X. Y. Mao,

    1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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  • X. L. Chang,

    1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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  • D. M. Zhao,

    1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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  • J. H. Zhang,

    1. Department of Internal Medicine, Wangjiang Hospital, Sichuan University, Chengdu, Sichuan Province, China
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  • W. J. Yu,

    1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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  • E. K. Tan,

    Corresponding author
    1. Duke–NUS Graduate Medical School, Singapore, Singapore
    2. Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore
    • R. Peng, Department of Neurology, West China Hospital, Sichuan University, Sichuan Province 610041, Chengdu, China

      Tel.: +86 28 85423038

      Fax: +86 28 85582944

      e-mail: qrpeng@hotmail.com

      and

      E. K. Tan, Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore

      Tel.: +65 6326 5003

      Fax: +65 6220 3221

      e-mail: gnrtek@sgh.com.sg

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  • R. Peng

    Corresponding author
    1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    • R. Peng, Department of Neurology, West China Hospital, Sichuan University, Sichuan Province 610041, Chengdu, China

      Tel.: +86 28 85423038

      Fax: +86 28 85582944

      e-mail: qrpeng@hotmail.com

      and

      E. K. Tan, Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore

      Tel.: +65 6326 5003

      Fax: +65 6220 3221

      e-mail: gnrtek@sgh.com.sg

    Search for more papers by this author

Abstract

Background

Genetic variability of methylenetetrahydrofolate reductase (MTHFR) may be associated with Parkinson's disease (PD). Its role in ethnic Chinese population is still unclear. Our study aimed to investigate whether MTHFR C677T variation was linked to PD risk in a Han Chinese population from mainland China.

Methods

To investigate the association with the risk of PD, we analyzed the single-nucleotide polymorphism C677T in MTHFR gene using a case–control methodology. A total of 1482 subjects included 765 patients with idiopathic PD, and 717 age- and sex-matched controls were recruited in this study.

Results

The T allele of MTHFR C677T was associated with a decreased risk of PD (OR = 0.80, 95% CI: 0.688–0.926, = 0.003). Patients with CT + TT genotypes have a decreased risk of PD compared with those with CC genotypes (OR = 0.66, 95%CI: 0.532–0.813, = 0.000). CT + TT subjects cannot be differentiated from CC subjects based on their clinical features.

Conclusion

We showed that the C677T polymorphism in MTHFR gene was associated with decreased PD susceptibility in a Han Chinese population from mainland China. Efforts to fully elucidate the pathophysiologic role of the variant in PD should be necessary.

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