MTHFR C677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese
Version of Record online: 17 MAR 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Neurologica Scandinavica
Volume 130, Issue 1, pages e30–e34, July 2014
How to Cite
MTHFR C677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese. Acta Neurol Scand 2014: 130: e30–e34. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., , , , , , , , .
- Issue online: 10 JUN 2014
- Version of Record online: 17 MAR 2014
- Manuscript Accepted: 11 FEB 2014
- Duke–NUS Graduate Medical School
- Singapore Millennium Foundation
- National Medical Research Council
- West China Hospital of Sichuan University
- Science and Technology Support Program of Sichuan province
- Parkinson's disease;
- SNP ;
- MTHFR C677T
Genetic variability of methylenetetrahydrofolate reductase (MTHFR) may be associated with Parkinson's disease (PD). Its role in ethnic Chinese population is still unclear. Our study aimed to investigate whether MTHFR C677T variation was linked to PD risk in a Han Chinese population from mainland China.
To investigate the association with the risk of PD, we analyzed the single-nucleotide polymorphism C677T in MTHFR gene using a case–control methodology. A total of 1482 subjects included 765 patients with idiopathic PD, and 717 age- and sex-matched controls were recruited in this study.
The T allele of MTHFR C677T was associated with a decreased risk of PD (OR = 0.80, 95% CI: 0.688–0.926, P = 0.003). Patients with CT + TT genotypes have a decreased risk of PD compared with those with CC genotypes (OR = 0.66, 95%CI: 0.532–0.813, P = 0.000). CT + TT subjects cannot be differentiated from CC subjects based on their clinical features.
We showed that the C677T polymorphism in MTHFR gene was associated with decreased PD susceptibility in a Han Chinese population from mainland China. Efforts to fully elucidate the pathophysiologic role of the variant in PD should be necessary.