A Reappraisal on Lidocaine-Sensitive Repetitive, Uniform Atrial Tachycardia

Authors

  • Hugo A. Garro M.D.,

    Corresponding author
    • Centro de Arritmias Cardíacas de la Ciudad de Buenos Aires, Division of Cardiology, Hospital J. M. Ramos Mejía, and Pontificia Universidad Católica Argentina “Santa María de los Buenos Aires”, Buenos Aires, Argentina
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  • Marcelo V. Elizari M.D., F.A.C.C.,

    1. Centro de Arritmias Cardíacas de la Ciudad de Buenos Aires, Division of Cardiology, Hospital J. M. Ramos Mejía, and Pontificia Universidad Católica Argentina “Santa María de los Buenos Aires”, Buenos Aires, Argentina
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  • Adrian Baranchuk M.D., F.A.C.C., F.R.C.P.C.,

    1. Heart Rhythm Service, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada
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  • Francisco Femenía M.D.,

    1. Servicio de Arritmias, Hospital Español, Mendoza, Argentina
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  • Pablo A. Chiale M.D.

    1. Centro de Arritmias Cardíacas de la Ciudad de Buenos Aires, Division of Cardiology, Hospital J. M. Ramos Mejía, and Pontificia Universidad Católica Argentina “Santa María de los Buenos Aires”, Buenos Aires, Argentina
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Address for correspondence: Hugo A. Garro, M.D., Centro de Arritmias Cardíacas de la Ciudad Autónoma de Buenos Aires, Division Cardiologia.Hospital J.M. Ramos Mejía, Buenos Aires, Argentina. Fax: 054 11 4956 2102; E-mail: hugoariel@garro.com

Abstract

Background

Lidocaine sensitive, repetitive atrial tachycardia is an unusual arrhythmia whose electrophysiologic substrate remains undefined. We aimed to analyze the electropharmacologic characteristics of this arrhythmia with emphasis on its cellular substrate and response to drug challenges.

Methods

We retrospectively analyzed a series of 18 patients from an electrocardiographic and electrophysiologic perspective and the response to pharmacological challenge.

Results

There was no evidence of structural heart disease in 12 patients, 4 patients presented with systemic hypertension; one patient had a prior myocardial infarction and one a mitral valve prolapse. The arrhythmia depicted a consistent pattern in nine patients. The first initiating ectopic beat showed a long coupling interval, the cycle length of the second atrial ectopic beat presented the shortest cycle length and a further prolongation was apparent towards the end of the atrial salvos. Conversely, in the other nine cases, the atrial tachycardia cycle length was erratic. The arrhythmia was suppressed by asynchronous atrial pacing at cycle lengths longer than those of the atrial tachycardia. Intravenous lidocaine eliminated the arrhythmia in all patients, but intravenous verapamil suppressed the atrial tachycardia in only two patients while adenosine caused a transient disappearance in 2/8 patients. Only one patient responded to all the three agents. Radiofrequency ablation was successfully performed in 10 patients.

Conclusions

Repetitive uniform atrial tachycardia can be sensitive to lidocaine. In few cases, this rare focal arrhythmia may be also suppressed by adenosine and/or verapamil, which suggests a diversity of electrophysiologic substrates that deserve to be accurately identified.

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