• Please log in or register to access this feature.

ORIGINAL ARTICLE

You have free access to this content

Associations between NOS1AP Single Nucleotide Polymorphisms (SNPs) and QT Interval Duration in Four Racial/Ethnic Groups in the Multi-Ethnic Study of Atherosclerosis (MESA)

  1. Sidharth A. Shah M.D., M.S.1,*,
  2. David M. Herrington M.D., M.H.S.1,2,
  3. Timothy D. Howard Ph.D.3,
  4. Jasmin Divers Ph.D.3,
  5. Donna K. Arnett Ph.D.4,
  6. Greg L. Burke M.D.2,
  7. Weng Hong Kao Ph.D.5,
  8. Xiuqing Guo Ph.D.6,
  9. David S. Siscovick M.D., M.P.H.7,
  10. Aravinda Chakravarti Ph.D.8,
  11. Joao A. Lima M.D.9,
  12. Bruce M. Psaty M.D., Ph.D., M.P.H.7,
  13. Gordon F. Tomaselli M.D.9,
  14. Stephen S. Rich Ph.D.10,
  15. Donald W. Bowden Ph.D.3,
  16. Wendy Post M.D., M.S.5,9

Article first published online: 24 JAN 2013

DOI: 10.1111/anec.12028

Issue

Annals of Noninvasive Electrocardiology

Annals of Noninvasive Electrocardiology

Volume 18, Issue 1, pages 29–40, January 2013

Additional Information

How to Cite

Shah, S. A., Herrington, D. M., Howard, T. D., Divers, J., Arnett, D. K., Burke, G. L., Hong Kao, W., Guo, X., Siscovick, D. S., Chakravarti, A., Lima, J. A., Psaty, B. M., Tomaselli, G. F., Rich, S. S., Bowden, D. W. and Post, W. (2013), Associations between NOS1AP Single Nucleotide Polymorphisms (SNPs) and QT Interval Duration in Four Racial/Ethnic Groups in the Multi-Ethnic Study of Atherosclerosis (MESA). Annals of Noninvasive Electrocardiology, 18: 29–40. doi: 10.1111/anec.12028

Author Information

  1. 1

    Section on Cardiology

  2. 2

    Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC

  3. 3

    Human Genomics

  4. 4

    Department of Epidemiology, University of Alabama-Birmingham, Birmingham, AL

  5. 5

    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health Baltimore, MD

  6. 6

    Mathematical Genetics, Cedars-Sinai Medical Center, Los Angeles, CA

  7. 7

    Cardiovascular Health Research Unit, University of Washington, Seattle, WA

  8. 8

    McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD

  9. 9

    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD

  10. 10

    Center for Public Health Genomics, University of Virginia, Charlottesville, VA

*Address for Correspondence: Sidharth Shah, M.D., M.S., 3000 New Bern Avenue, Suite G100, Raleigh, NC 27610. Fax: +336-716-9188; E-mail: sidharth.a.shah@gmail.com

  1. Conflict of Interest Disclosures: Tomaselli: Research Grant–Boston Scientific >$10,000. All others: none.

Publication History

  1. Issue published online: 24 JAN 2013
  2. Article first published online: 24 JAN 2013

Funded by

  • NIH. Grant Numbers: R01HL076438, HL076132, N01-HC-95159, N01-HC-95169, RO1 HL071205

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (784K)

REFERENCES

  • 1
    Thom T, Haase N, Rosamond W, et al. Heart disease and stroke statistics–2006 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006;113:e85–151.
  • 2
    Arking DE, Junttila MJ, Goyette P, et al. Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet 2011;7:e1002158.
  • 3
    Schouten EG, Dekker JM, Meppelink P, et al. Qt inter-val prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation 1991;84:1516–1523.
  • 4
    Dekker JM, Crow RS, Hannan PJ, et al. Heart rate-corrected Qt interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: The aric study. J Am Coll Cardiol 2004;43:565–571.
  • 5
    Okin PM, Devereux RB, Howard BV, et al. Assessment of Qt interval and Qt dispersion for prediction of all-cause and cardiovascular mortality in american indians: The strong heart study. Circulation 2000;101:61–66.
  • 6
    Pfeufer A, Jalilzadeh S, Perz S, et al. Common variants in myocardial ion channel genes modify the qt interval in the general population: Results from the kora study. Circ Res 2005;96:693–701.
  • 7
    Arking DE, Pfeufer A, Post W, et al. A common genetic variant in the nos1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 2006;38:644–651.
  • 8
    Aarnoudse AJ, Newton-Cheh C, de Bakker PI, et al. Common NOS1AP variants are associated with a prolonged qtc interval in the Rotterdam study. Circulation 2007;116:10–16.
  • 9
    Post W, Shen H, Damcott C, et al. Associations between genetic variants in the NOS1AP (capon) gene and cardiac repolarization in the old order amish. Hum Hered 2007;64:214–219.
  • 10
    Tobin MD, Kahonen M, Braund P, et al. Gender and effects of a common genetic variant in the nos1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations. Int J Epidemiol 2008;37:1132–1141.
  • 11
    Kao WH, Arking DE, Post W, et al. Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in us white community-based populations. Circulation 2009;119:940–951.
  • 12
    Lehtinen AB, Newton-Cheh C, Ziegler JT, et al. Association of NOS1AP genetic variants with Qt interval duration in families from the diabetes heart study. Diabetes 2008;57:1108–1114.
  • 13
    Raitakari OT, Blom-Nyholm J, Koskinen TA, et al. Common variation in NOS1AP and kcnh2 genes and qt interval duration in young adults. The cardiovascular risk in young Finns study. Ann Med 2009;41:144–151.
  • 14
    Chang KC, Barth AS, Sasano T, et al. Capon modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proc Natl Acad Sci U S A 2008;105:4477–4482.
  • 15
    Xu B, Wratten N, Charych EI, et al. Increased expression in dorsolateral prefrontal cortex of capon in schizophrenia and bipolar disorder. PLoS Med 2005;2:e263.
  • 16
    Khan SA, Lee K, Minhas KM, et al. Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A 2004;101:15944–15948.
  • 17
    Segalat L, Grisoni K, Archer J, et al. Capon expression in skeletal muscle is regulated by position, repair, nos activity, and dystrophy. Exp Cell Res 2005;302:170–179.
  • 18
    Arking DE, Khera A, Xing C, et al. Multiple independent genetic factors at NOS1AP modulate the qt interval in a multi-ethnic population. PLoS ONE 2009;4:e4333.
  • 19
    Lu J, Hu C, Hu W, et al. A common variant of NOS1AP is associated with QT interval duration in a Chinese population with type 2 diabetes. Diabet Med 2010; 27:1074–1079.
    Direct Link:
  • 20
    Bild DE, Bluemke DA, Burke GL, et al. Multi-ethnic study of atherosclerosis: Objectives and design. Am J Epidemiol 2002;156:871–881.
  • 21
    Gunderson KL, Kruglyak S, Graige MS, et al. Decoding randomly ordered DNA arrays. Genome Res 2004;14:870–877.
  • 22
    Fan JB, Gunderson KL, Bibikova M, et al. Illumina universal bead arrays. Methods Enzymol 2006;410:57–73.
  • 23
    de Bakker PI, Yelensky R, Pe'er I, et al. Efficiency and power in genetic association studies. Nat Genet 2005;37:1217–1223.
  • 24
    Barrett JC, Fry B, Maller J, et al. Haploview: Analysis and visualization of ld and haplotype maps. Bioinformatics 2005;21:263–265.
  • 25
    The international hapmap project. Nature 2003;426:789–796.
  • 26
    Seldin MF, Tian C, Shigeta R, et al. Argentine population genetic structure: Large variance in amerindian contribution. Am J Phys Anthropol 2007;132:455–462.
    Direct Link:
  • 27
    Choudhry S, Coyle NE, Tang H, et al. Population stratification confounds genetic association studies among latinos. Hum Genet 2006;118:652–664.
  • 28
    Bazett HC: An analysis of the time-relations of electrocardiograms. Heart J Study Circ 1920;353–370.
  • 29
    Newton-Cheh C, Eijgelsheim M, Rice KM, et al. Common variants at ten loci influence Qt interval duration in the Qtgen study. Nat Genet 2009;41:399–406.
  • 30
    Wacholder S, Rothman N, Caporaso N: Population stratification in epidemiologic studies of common genetic variants and cancer: Quantification of bias. J Natl Cancer Inst 2000;92:1151–1158.
  • 31
    Witte JS, Gauderman WJ, Thomas DC: Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: Basic family designs. Am J Epidemiol 1999;149:693–705.
View Full Article (HTML) Get PDF (784K)