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Effects of intracerebroventricular treatment with oleate or octanoate on fatty acid metabolism in Brockmann bodies and liver of rainbow trout

Authors

  • M. Librán-Pérez,

    1. Laboratorio de Fisioloxía Animal, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, Vigo, Spain
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  • C. Otero-Rodiño,

    1. Laboratorio de Fisioloxía Animal, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, Vigo, Spain
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  • M.A. López-Patiño,

    1. Laboratorio de Fisioloxía Animal, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, Vigo, Spain
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  • J.M. Míguez,

    1. Laboratorio de Fisioloxía Animal, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, Vigo, Spain
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  • J.L. Soengas

    Corresponding author
    1. Laboratorio de Fisioloxía Animal, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, Vigo, Spain
    • Correspondence: J.L. Soengas, Laboratorio de Fisioloxía Animal, Departamentode Bioloxía Funcional e Ciencias da Saúde, Edificio de Ciencias Experimentais, Universidade de Vigo, E-36310 Vigo, Spain. E-mail: jsoengas@uvigo.es

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Abstract

Intracerebroventricular (ICV) treatment with oleate or octanoate induced in Brockmann bodies (BB) and liver of rainbow trout changes in several parameters related to fatty acid (FA) sensing through FA metabolism, FA transport through FA translocase (FAT/CD36) and mitochondrial activity. Changes observed in BB were completely different to those observed in previous studies after treatment with the same FA either intraperitoneal (IP) or in vitro. Therefore, FA sensing in BB is apparently direct and not related to previous FA sensing in hypothalamus, but it could be influenced by changes in the levels of peripheral hormones like insulin. In contrast, results obtained after ICV treatment with FA in liver were comparable to those observed after IP treatment but different to those observed after in vitro treatment. Therefore, FA sensing in liver is apparently indirect and be the consequence of previous hypothalamic FA sensing followed by vagal and/or sympathetic outflow.

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