Conflict of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article.
SHORT RESEARCH REPORT
Cord blood C-peptide levels relate to the metabolic profile of women with and without gestational diabetes
Article first published online: 1 NOV 2012
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology
Acta Obstetricia et Gynecologica Scandinavica
Volume 91, Issue 12, pages 1469–1473, December 2012
How to Cite
DUBÉ, M.-C., MORISSET, A.-S., TCHERNOF, A. and WEISNAGEL, S. J. (2012), Cord blood C-peptide levels relate to the metabolic profile of women with and without gestational diabetes. Acta Obstetricia et Gynecologica Scandinavica, 91: 1469–1473. doi: 10.1111/aogs.12005
Please cite this article as: Dubé M-C, Morisset A-S, Tchernof A, Weisnagel SJ. Cord blood C-peptide levels relate to the metabolic profile of women with and without gestational diabetes. Acta Obstet Gynecol Scand. 2012;91:DOI: 10.1111/aogs.12005.
- Issue published online: 5 DEC 2012
- Article first published online: 1 NOV 2012
- Accepted manuscript online: 20 SEP 2012 07:56AM EST
- Received: 16 January 2012 Accepted: 21 August 2012
- Gestational diabetes;
- cord blood C-peptide;
- insulin sensitivity;
- glucose-insulin homeostasis
Plasma C-peptide reflects the insulin-secretory activity of pancreatic β-cells which modulates fetal growth. Cord blood C-peptide levels were measured in women with gestational diabetes mellitus (GDM) and in women with normal glucose tolerance (NGT). Forty-one women underwent a 75-g oral glucose tolerance test (18 GDM, 23 NGT). Cord blood C-peptide (p = 0.09) and glucose levels (p = 0.08) from newborns of GDM women tended to be higher than those from NGT women. In the entire group, cord blood C-peptide correlated with maternal insulin, fasting C-peptide, insulin sensitivity, interleukin-6, weight and body mass index measured at screening (ρ from 0.34 to 0.48, all p < 0.05) and tended to correlate with offspring weight (ρ = 0.28, p = 0.08). Newborns of GDM women tended to have elevated cord blood C-peptide which correlated with maternal insulin, insulin sensitivity and anthropometric measures at diagnosis and with offspring characteristics. This suggests that insulin-secretory activity of the newborn is related to maternal metabolic parameters.