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Cord blood C-peptide levels relate to the metabolic profile of women with and without gestational diabetes

Authors

  • MARIE-CHRISTINE DUBÉ,

    1. Endocrinology and Genomics, Laval University Medical Research Center
    2. Diabetes Research Unit, Laval University Medical Research Center
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  • ANNE-SOPHIE MORISSET,

    1. Endocrinology and Genomics, Laval University Medical Research Center
    2. Department of Food Science and Nutrition, Laval University
    3. Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada
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  • ANDRÉ TCHERNOF,

    1. Endocrinology and Genomics, Laval University Medical Research Center
    2. Department of Food Science and Nutrition, Laval University
    3. Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada
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  • S. JOHN WEISNAGEL

    1. Endocrinology and Genomics, Laval University Medical Research Center
    2. Diabetes Research Unit, Laval University Medical Research Center
    3. Department of Food Science and Nutrition, Laval University
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  • Conflict of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article.

  • Please cite this article as: Dubé M-C, Morisset A-S, Tchernof A, Weisnagel SJ. Cord blood C-peptide levels relate to the metabolic profile of women with and without gestational diabetes. Acta Obstet Gynecol Scand. 2012;91:DOI: 10.1111/aogs.12005.

Dr. S. John Weisnagel, Diabetes Research Unit, CRCHUL, room TR-27, 2705 boul. Laurier, Quebec, QC, G1V 4G2, Canada. E-mail: john.weisnagel@crchul.ulaval.ca

Abstract

Plasma C-peptide reflects the insulin-secretory activity of pancreatic β-cells which modulates fetal growth. Cord blood C-peptide levels were measured in women with gestational diabetes mellitus (GDM) and in women with normal glucose tolerance (NGT). Forty-one women underwent a 75-g oral glucose tolerance test (18 GDM, 23 NGT). Cord blood C-peptide (p = 0.09) and glucose levels (p = 0.08) from newborns of GDM women tended to be higher than those from NGT women. In the entire group, cord blood C-peptide correlated with maternal insulin, fasting C-peptide, insulin sensitivity, interleukin-6, weight and body mass index measured at screening (ρ from 0.34 to 0.48, all p < 0.05) and tended to correlate with offspring weight (ρ = 0.28, p = 0.08). Newborns of GDM women tended to have elevated cord blood C-peptide which correlated with maternal insulin, insulin sensitivity and anthropometric measures at diagnosis and with offspring characteristics. This suggests that insulin-secretory activity of the newborn is related to maternal metabolic parameters.

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