Conflict of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article.
MAIN RESEARCH ARTICLE
Ethnic disparities in the risk of adverse neonatal outcome after spontaneous preterm birth
Article first published online: 1 NOV 2012
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology
Acta Obstetricia et Gynecologica Scandinavica
Volume 91, Issue 12, pages 1402–1408, December 2012
How to Cite
SCHAAF, J. M., MOL, B.-W. J., ABU-HANNA, A. and RAVELLI, A. C.J. (2012), Ethnic disparities in the risk of adverse neonatal outcome after spontaneous preterm birth. Acta Obstetricia et Gynecologica Scandinavica, 91: 1402–1408. doi: 10.1111/aogs.12013
Please cite this article as: Schaaf JM, Mol B-WJ, Abu-Hanna A, Ravelli ACJ. Ethnic disparities in the risk of adverse neonatal outcome after spontaneous preterm birth. Acta Obstet Gynecol Scand 2012; 91: DOI: 10.1111/aogs.12013.
- Issue published online: 5 DEC 2012
- Article first published online: 1 NOV 2012
- Accepted manuscript online: 24 SEP 2012 10:20PM EST
- Received: 25 April 2012 Accepted: 14 September 2012
- neonatal morbidity;
- neonatal mortality;
- perinatal outcome;
- spontaneous preterm birth
Objective. To describe ethnic disparities in the risk of spontaneous preterm birth and related adverse neonatal outcome. Design. Nationwide prospective cohort study. Setting. The Netherlands, 1999–2007. Population. Nine hundred and sixty-nine thousand, four hundred and ninety-one singleton pregnancies with a spontaneous onset of labor. Methods. We investigated ethnic disparities in perinatal outcome for European white, African, South-Asian, Mediterranean and East-Asian women. We performed multivariate logistic regression analyses to calculate the adjusted odds ratio (aOR) and confidence intervals (CIs) of spontaneous preterm birth and the risk of subsequent neonatal morbidity and mortality. Main outcome measures. The primary outcome measure was spontaneous preterm birth before 37 completed weeks of gestation. Secondarily, we investigated subsequent adverse neonatal outcome, which was a composite outcome of intraventricular hemorrhage, bronchopulmonary dysplasia, infant respiratory distress syndrome, neonatal sepsis or neonatal mortality within 28 days after birth. Results. Compared with European whites, the aOR of delivering preterm was 1.33 (95% CI 1.26–1.41) for African women, 1.58 (95% CI 1.47–1.69) for South-Asians, 0.88 (95% CI 0.84–0.91) for Mediterraneans and 1.04 (95% CI 0.98–1.11) for East-Asians. Subsequent odds of adverse neonatal outcome were significantly lower for African (aOR 0.51; 95% CI 0.41–0.64) and Mediterranean women (aOR 0.86; 95% CI 0.75–0.99) when compared with European whites. Conclusions. African and South-Asian women are at higher risk for preterm birth than European white women. However, the harmful effect of preterm birth on neonatal outcome is less severe for these women.