Conflict of interest
Short Research Report
Involvement of inflammation in normal pregnancy
Article first published online: 18 MAR 2013
© 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology
Acta Obstetricia et Gynecologica Scandinavica
Volume 92, Issue 5, pages 601–605, May 2013
How to Cite
Involvement of inflammation in normal pregnancy. Acta Obstet Gynecol Scand 2013; 92: 601–605., , , , .
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
- Issue published online: 17 APR 2013
- Article first published online: 18 MAR 2013
- Manuscript Accepted: 7 JAN 2013
- Manuscript Received: 23 FEB 2012
- foundation of Gillbergska
- Perinatal Research Foundation
- General Maternity Hospital Foundation
- tumor necrosis factor-α;
- prostaglandin F2α
To study the role of inflammation throughout normal pregnancy and postpartum, 37 women with normal pregnancies, including normal neonatal outcome, participated. Blood and urine samples were collected from each woman at least six times during pregnancy and postpartum. Plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and urinary levels of a prostaglandin-F2α (PGF2α) metabolite were measured. Median, 25th to 75th centile and average change per gestational week of IL-6, TNF-α and the PGF2α metabolite were measured. Levels of IL-6 increased significantly throughout pregnancy and remained high postpartum. No change in TNF-α could be seen. The PGF2α metabolite levels increased significantly throughout pregnancy and decreased postpartum. These results suggest that mild but significant inflammatory activity is involved in the development of normal pregnancy, which might have important physiological roles.