Involvement of inflammation in normal pregnancy

Authors

  • Maria Palm,

    Corresponding author
    • Department of Women's and Children's Health, Obstetrics and Gynecology Uppsala University, Uppsala, Sweden
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  • Ove Axelsson,

    1. Department of Women's and Children's Health, Obstetrics and Gynecology Uppsala University, Uppsala, Sweden
    2. Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden
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  • Lisa Wernroth,

    1. Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
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  • Anders Larsson,

    1. Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
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  • Samar Basu

    1. Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    2. Laboratory of Biochemistry, Molecular Biology and Nutrition, Faculty of Pharmacy, University of Auvergne, Clermont-Ferrand, France
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  • Conflict of interest

    The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Correspondence

Maria Palm, Department of Women's and Children's Health, Obstetrics and Gynecology, Uppsala University, SE-751 85 Uppsala, Sweden. E-mail: maria.palm@kbh.uu.se

Abstract

To study the role of inflammation throughout normal pregnancy and postpartum, 37 women with normal pregnancies, including normal neonatal outcome, participated. Blood and urine samples were collected from each woman at least six times during pregnancy and postpartum. Plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and urinary levels of a prostaglandin-F (PGF) metabolite were measured. Median, 25th to 75th centile and average change per gestational week of IL-6, TNF-α and the PGF metabolite were measured. Levels of IL-6 increased significantly throughout pregnancy and remained high postpartum. No change in TNF-α could be seen. The PGF metabolite levels increased significantly throughout pregnancy and decreased postpartum. These results suggest that mild but significant inflammatory activity is involved in the development of normal pregnancy, which might have important physiological roles.

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