The authors have all stated explicitly that there are no conflicts of interest in connection with this article.
Main Research Article
Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women
Article first published online: 1 MAR 2013
© 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology
Acta Obstetricia et Gynecologica Scandinavica
Volume 92, Issue 5, pages 591–597, May 2013
How to Cite
Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women. Acta Obstet Gynecol Scand 2013; 92: 591–597., , , , , , , , , .
- Issue published online: 17 APR 2013
- Article first published online: 1 MAR 2013
- Accepted manuscript online: 31 JAN 2013 05:50PM EST
- Manuscript Accepted: 11 JAN 2013
- Manuscript Received: 23 OCT 2012
- Hungarian Scientific Research Foundation. Grant Numbers: OTKA K-68758, OTKA 68808
- Hungarian Respiratory Society grant
- Airway inflammation;
- asthmatic pregnancy;
- exhaled breath condensate pH;
- healthy pregnancy;
- neonatal birthweight
Asthma is a common chronic disease complicating pregnancy with a risk for perinatal complications. Control of airway inflammation in the asthmatic pregnancy improves pregnancy outcomes. Our aim was to evaluate pH of exhaled breath condensate (EBC), a non-invasive method for the assessment of asthmatic airway inflammation, in healthy and asthmatic pregnancies.
Hungarian university clinics.
Seventeen healthy pregnant women, 21 asthmatic pregnant women, 23 healthy non-pregnant women and 22 asthmatic non-pregnant women.
EBC samples were collected using a portable condenser, EBC pH was measured after argon deaeration.
Main outcome measure
EBC pH (mean ± SD) of healthy non-pregnant and asthmatic non-pregnant women was similar (7.75 ± 0.27 vs. 7.54 ± 0.57; p = 0.118), probably indicating an optimal control of airway inflammation in asthmatic women. On the other hand, EBC pH was higher in healthy pregnant women compared with healthy non-pregnant women (8.02 ± 0.43 vs. 7.75 ± 0.27; p = 0.017). Higher EBC pH accompanying healthy pregnancy was absent in asthmatic pregnant patients whose EBC pH was lower (7.65 ± 0.38) than that of healthy pregnant women (p = 0.006), and it was similar to that in asthmatic and healthy non-pregnant women (p = 0.470 and p = 0.300, respectively). The EBC pH in asthmatic pregnant women correlated positively with birthweight (r = 0.49, p = 0.047) and negatively with forced vital capacity (r = 0.45, p = 0.039). EBC pH was not related to blood pH.
EBC pH is higher in healthy pregnant women but not in asthmatic pregnant women compared with data from healthy non-pregnant women, indicating that oxidative inflammatory processes induced by asthma may compromise the regulatory mechanisms causing alkaline pH in the airways during pregnancy.