Fetal death and placental weight/birthweight ratio: a population study

Authors

  • Camilla Haavaldsen,

    Corresponding author
    • Department of Gynecology and Obstetrics, Akershus University Hospital and Institute of Clinical Medicine, University of Oslo, Lørenskog, Norway
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  • Sven O. Samuelsen,

    1. Department of Mathematics, University of Oslo, Oslo, Norway
    2. Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
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  • Anne Eskild

    1. Department of Gynecology and Obstetrics, Akershus University Hospital and Institute of Clinical Medicine, University of Oslo, Lørenskog, Norway
    2. Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
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  • The authors have stated explicitly that there are no conflicts of interest in connection with this article.

Correspondence

Camilla Haavaldsen, Department of Gynecology and Obstetrics, Akershus University Hospital, Lørenskog N-1478, Norway. E-mail: marit.camilla.haavaldsen@ahus.no

Abstract

Objective

To study the association of placental weight and placental weight/birthweight ratio with gestational age-specific fetal death.

Design

Population-based study.

Setting

Medical Birth Registry of Norway.

Population

All singleton births in Norway, 1999–2008 (n = 534 892).

Methods

Gestational age-specific quartiles of placental weight and placental weight/birthweight ratio were estimated, and proportions of fetal deaths and live births within the lowest and highest quartile were compared. The risk of fetal death associated with placental weight/birthweight ratio was estimated as crude and adjusted odds ratios.

Main outcome measures

Offspring vital status.

Results

Pregnancies with fetal death were overrepresented in the lowest quartile of placental weight and placental weight/birthweight ratio in term and preterm deliveries. In preterm deliveries, fetal deaths were also overrepresented in the highest placental weight/birthweight ratio. Adjusted odds ratio of fetal death in preterm deliveries was 1.67 (95% confidence interval 1.44–1.94) for placental weight/birthweight ratio in the lowest quartile and 1.79 (95% confidence interval 1.55–2.08) in the highest quartile. Corresponding odds ratios for deliveries at term were 1.76 (95% confidence interval 1.50–2.06) and 1.18 (95% confidence interval 0.99–1.41).

Conclusions

Both small and large placentas relative to birthweight were associated with fetal death in preterm births. At term, only small placentas relative to birthweight were associated with fetal death. Understanding the mechanisms behind the increased risk of adverse pregnancy outcomes in pregnancies with disproportionate placental weight/birthweight ratio may be important for prevention of fetal deaths.

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