The authors have stated explicitly that there are no conflicts of interest in connection with this article.
Main Research Article
Fetal death and placental weight/birthweight ratio: a population study
Article first published online: 1 MAR 2013
© 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology
Acta Obstetricia et Gynecologica Scandinavica
Volume 92, Issue 5, pages 583–590, May 2013
How to Cite
Fetal death and placental weight/birthweight ratio: a population study. Acta Obstet Gynecol Scand 2013; 92: 583–590., , .
- Issue published online: 17 APR 2013
- Article first published online: 1 MAR 2013
- Accepted manuscript online: 7 FEB 2013 02:24PM EST
- Manuscript Accepted: 21 DEC 2012
- Manuscript Received: 5 JUL 2012
- South-Eastern Regional Health Authority
- fetal death;
- high-risk pregnancy;
- placental weight;
To study the association of placental weight and placental weight/birthweight ratio with gestational age-specific fetal death.
Medical Birth Registry of Norway.
All singleton births in Norway, 1999–2008 (n = 534 892).
Gestational age-specific quartiles of placental weight and placental weight/birthweight ratio were estimated, and proportions of fetal deaths and live births within the lowest and highest quartile were compared. The risk of fetal death associated with placental weight/birthweight ratio was estimated as crude and adjusted odds ratios.
Main outcome measures
Offspring vital status.
Pregnancies with fetal death were overrepresented in the lowest quartile of placental weight and placental weight/birthweight ratio in term and preterm deliveries. In preterm deliveries, fetal deaths were also overrepresented in the highest placental weight/birthweight ratio. Adjusted odds ratio of fetal death in preterm deliveries was 1.67 (95% confidence interval 1.44–1.94) for placental weight/birthweight ratio in the lowest quartile and 1.79 (95% confidence interval 1.55–2.08) in the highest quartile. Corresponding odds ratios for deliveries at term were 1.76 (95% confidence interval 1.50–2.06) and 1.18 (95% confidence interval 0.99–1.41).
Both small and large placentas relative to birthweight were associated with fetal death in preterm births. At term, only small placentas relative to birthweight were associated with fetal death. Understanding the mechanisms behind the increased risk of adverse pregnancy outcomes in pregnancies with disproportionate placental weight/birthweight ratio may be important for prevention of fetal deaths.