The clinical picture of juvenile parotitis in a prospective setup

Authors


  • The study has been approved by the Institutional Ethic’s Comittee.

Riitta Saarinen, Department of Otorhinolaryngology, Helsinki University Central Hospital, POB 220, 00029 HUS Helsinki, Finland.
Tel: +358-50-4271-496 |
Fax: +358-9-4717 6561|
Email: riitta.t.saarinen@hus.fi

Abstract

Aim:  To characterize the features of juvenile parotitis in a prospective setup and epidemiology.

Methods:  All children with parotitis admitted to Helsinki University Central Hospital 2005–2010 were recruited. Clinical characteristics, given treatment, outcome, blood leukocyte count, C-reactive protein, serum amylase and trypsinogen, SPINK-1 genotype and mumps antibodies were recorded. To map the epidemiology, a questionnaire was sent to 1000 randomly selected 13-year-old children.

Results:  The prospective study included 41 children (aged ≤ 17) with acute parotitis, all in good general condition. Serum amylase, but not trypsinogen, was elevated in majority of the cases (79%) and C-reactive protein in 68%. Eleven (27%) children had an elevated blood leukocyte count. None had acute mumps. Most children recovered well, 51% being treated symptomatically only. Seven children were treated on ward. Seventeen (46%) children had recurrent symptoms. One child (2.4%) had SPINK P55S mutation. According to the epidemiological questionnaire, 1.1% of the respondents (8/728, response rate 73%) reported a verified episode(s) of parotitis.

Conclusion:  Juvenile parotitis has a frequency close to 1%. In the majority, the general condition is good during the episode. Serum amylase serves as an additional marker for the disease. Parotitis has a tendency to recur in almost half of the cases.

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