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Keywords:

  • Necrotizing enterocolitis;
  • Packed red blood cell transfusion;
  • Patent ductus arteriosus;
  • Preterm infant

Abstract

Aim:  Both patent ductus arteriosus (PDA) and packed red blood cell (PRBC) transfusion are risk factors for necrotizing enterocolitis (NEC). The combination of PDA and PRBC transfusion may have a synergistic effect on the intestinal circulation.

Methods:  We present four cases of NEC in very low birth weight (VLBW) infants within 14 h after PRBC transfusion.

Results:  All infants were growing on full enteral feeding, and they all had a PDA.

Conclusion:  We are concerned that the simultaneous presence of a PDA and PRBC transfusion in VLBW infants may place the infant at even greater risk of NEC than each of these factors alone.