Necrotizing enterocolitis after red blood cell transfusion in preterm infants with patent ductus arteriosus: a case series
Article first published online: 23 SEP 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 12, pages e570–e572, December 2012
How to Cite
Sellmer, A., Tauris, L. H., Johansen, A. and Henriksen, T. B. (2012), Necrotizing enterocolitis after red blood cell transfusion in preterm infants with patent ductus arteriosus: a case series. Acta Paediatrica, 101: e570–e572. doi: 10.1111/apa.12016
- Issue published online: 8 NOV 2012
- Article first published online: 23 SEP 2012
- Accepted manuscript online: 31 AUG 2012 09:10AM EST
- Received 5 December 2011; revised 1 August 2012; accepted 28 August 2012.
- Necrotizing enterocolitis;
- Packed red blood cell transfusion;
- Patent ductus arteriosus;
- Preterm infant
Aim: Both patent ductus arteriosus (PDA) and packed red blood cell (PRBC) transfusion are risk factors for necrotizing enterocolitis (NEC). The combination of PDA and PRBC transfusion may have a synergistic effect on the intestinal circulation.
Methods: We present four cases of NEC in very low birth weight (VLBW) infants within 14 h after PRBC transfusion.
Results: All infants were growing on full enteral feeding, and they all had a PDA.
Conclusion: We are concerned that the simultaneous presence of a PDA and PRBC transfusion in VLBW infants may place the infant at even greater risk of NEC than each of these factors alone.