Neurodevelopmental outcome at 6 years of age after intrauterine laser therapy for twin-twin transfusion syndrome
Article first published online: 29 SEP 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 12, pages 1200–1205, December 2012
How to Cite
Graeve, P., Banek, C., Stegmann-Woessner, G., Maschke, C., Hecher, K. and Bartmann, P. (2012), Neurodevelopmental outcome at 6 years of age after intrauterine laser therapy for twin-twin transfusion syndrome. Acta Paediatrica, 101: 1200–1205. doi: 10.1111/apa.12017
- Issue published online: 8 NOV 2012
- Article first published online: 29 SEP 2012
- Accepted manuscript online: 4 SEP 2012 10:49AM EST
- Received 27 March 2012; revised 27 August 2012; accepted 30 August 2012.
- Intrauterine laser therapy;
- Neurodevelopmental outcome;
- Twin-twin transfusion syndrome
This study was undertaken to evaluate neurodevelopmental outcome of children at 6 years of age after intrauterine laser therapy for Twin-twin transfusion syndrome (TTTS).
This is part of a longitudinal study in children after intrauterine laser therapy for TTTS; 190 of 254 (74.8%) children, previously investigated at a median age of 2 years 10 months, were re-evaluated at 6 years 5 months (range 4 years 11 months –10 years 4 months). Sixty-four patients were not examined due to loss of contact. The median gestational age at birth was 34 + 3 weeks. The study included a physical/neurological examination, a standardized neurodevelopmental test (Kaufman-ABC) and/or results from the national screening programme for children as well as questionnaires. Patients were grouped in three outcome categories: group I: normal examination and test result; group II: minor neurological deficiencies and normal test results; group III: major neurological deficiencies and/or test results below minus two standard deviations.
The following results were obtained at 6 years 5 months (for comparison, results of the same patients at 2 years 10 months in brackets). Group I: 79.5% (84.2%); group II: 11.6% (8.9%); group III: 8.9% (6.8%). Twenty-one (11%) patients had a worse and 8 (4.2%) an improved classification at 6 years 5 months as compared to 2 years 10 months. Overall, the results with 6 years did not significantly differ from the results with 2 years.
Neurodevelopmental outcome at 6 years 5 months was not statistically, significantly different from outcome at 2 years 10 months.