Sleep disorders in boys with Duchenne muscular dystrophy
Article first published online: 8 OCT 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 12, pages 1265–1269, December 2012
How to Cite
Bloetzer, C., Jeannet, P.-Y., Lynch, B. and Newman, C. J. (2012), Sleep disorders in boys with Duchenne muscular dystrophy. Acta Paediatrica, 101: 1265–1269. doi: 10.1111/apa.12025
- Issue published online: 8 NOV 2012
- Article first published online: 8 OCT 2012
- Accepted manuscript online: 26 SEP 2012 09:18AM EST
- Received 23 July 2012; revised 27 August 2012; accepted 7 September 2012.
- Duchenne muscular dystrophy;
- Sleep disorders;
- Steroid therapy
Aim: Determine the frequency and predictors of sleep disorders in boys with Duchenne Muscular Dystrophy (DMD).
Method: Cross-sectional study by postal questionnaire. Sleep disturbances were assessed using the Sleep Disturbance Scale for Children (validated on 1157 healthy children). A total sleep score and six sleep disturbance factors representing the most common sleep disorders were computed. Potential associations between pathological scores and personal, medical and environmental factors were assessed.
Results: Sixteen of 63 boys (25.4%) had a pathological total sleep score compared with 3% in the general population. The most prevalent sleep disorders were disorders of initiating and maintaining sleep (DIMS) 29.7%, sleep-related breathing disorders 15.6% and sleep hyperhydrosis 14.3%.
On multivariate analysis, pathological total sleep scores were associated with the need to be moved by a carer (OR = 9.4; 95%CI: 2.2–40.7; p = 0.003) and being the child of a single-parent family (OR = 7.2; 95%CI: 1.5–35.1; p = 0.015) and DIMS with the need to be moved by a carer (OR = 18.0; 95%CI: 2.9–110.6; p = 0.002), steroid treatment (OR = 7.7; 95%CI: 1.4–44.0; p = 0.021) and being the child of a single-parent family (OR = 7.0; 95%CI: 1.3–38.4; p = 0.025).
Conclusion: Sleep disturbances are frequent in boys with DMD and are strongly associated with immobility. Sleep should be systematically assessed in DMD to implement appropriate interventions.