Markers for severity of illness associated with decreased snoring in toddlers born ELGA
Article first published online: 1 NOV 2012
©2012 The Author(s)/Acta Pædiatrica ©2012 Foundation Acta Pædiatrica
Volume 102, Issue 1, pages e39–e43, January 2013
How to Cite
Wang, K., DiFiore, J. M., Martin, R. J., Rosen, C. L. and Hibbs, A. M. (2013), Markers for severity of illness associated with decreased snoring in toddlers born ELGA. Acta Paediatrica, 102: e39–e43. doi: 10.1111/apa.12033
- Issue published online: 11 DEC 2012
- Article first published online: 1 NOV 2012
- Accepted manuscript online: 26 SEP 2012 12:03AM EST
- Manuscript Accepted: 14 SEP 2012
- Manuscript Revised: 23 AUG 2012
- Manuscript Received: 19 JUN 2012
- Rainbow Fellowship Research Award Program. Grant Numbers: 5T32HD060537-02, 5R03HD064830-02, K23HD056299, 5U10HD021364-24
- Sleep disordered breathing;
To describe the prevalence of paediatric sleep disordered breathing (SDB) symptoms in extremely low gestational age infants and identify neonatal risk factors, including early exposure to hypoxia and hyperoxia.
Patients <28 weeks gestation were monitored with high-resolution pulse oximetry. Hypoxia/hyperoxia variables were defined as percentage time of first 4 weeks of life that SaO2 < 80% or SaO2 > 98%, respectively. Parents completed part of the OSA-18 questionnaire for symptoms of SDB at 18–22 months. Logistic regression was used to test the association between risk factors and sleep symptoms.
Of 182 patients recruited, 138 (76%) completed the questionnaire. The mean gestation was 26 weeks, and mean birth weight 887 grams. Loud snoring (21%) and restless sleep (24%) were the most prevalent symptoms. Female sex was associated with an increased risk of loud snoring (OR, 2.7; CI, 1.13–6.5). Prolonged mechanical ventilation, necrotizing enterocolitis and prolonged caffeine use, however, were inversely correlated with loud snoring. Neither neonatal hypoxia nor hyperoxia were associated with sleep symptoms.
While the prevalence of sleep disordered breathing symptoms is similar to reported rates, we found a sex difference not previously reported. Interestingly, markers for severity of illness show a pattern of being protective against loud snoring.