Expressed breast milk for procedural pain in preterm neonates: a randomized, double-blind, placebo-controlled trial
Article first published online: 1 NOV 2012
©2012 The Author(s)/Acta Pædiatrica ©2012 Foundation Acta Pædiatrica
Volume 102, Issue 1, pages 15–21, January 2013
How to Cite
Ou-Yang, M.-C., Chen, I.-L., Chen, C.-C., Chung, M.-Y., Chen, F.-S. and Huang, H.-C. (2013), Expressed breast milk for procedural pain in preterm neonates: a randomized, double-blind, placebo-controlled trial. Acta Paediatrica, 102: 15–21. doi: 10.1111/apa.12045
- Issue published online: 11 DEC 2012
- Article first published online: 1 NOV 2012
- Accepted manuscript online: 12 OCT 2012 02:15AM EST
- Manuscript Accepted: 26 SEP 2012
- Manuscript Revised: 12 SEP 2012
- Manuscript Received: 28 APR 2012
- Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine. Grant Number: CMRPG880121
- Expressed breast milk;
- Preterm infants;
- Randomized controlled trial
To determine whether expressed breast milk (milk) reduces procedural pain associated with heel lancing in preterm neonates.
In this placebo-controlled trial, preterm neonates received 5 mL of distilled water as placebo (water, n = 44), 25% glucose water (glucose, n = 39) or milk (n = 40). Heel lancing was performed 2 min later. The primary outcome was the duration of first cry after lancing.
Participants had similar baseline demographic and clinical characteristics. There was a significant difference in the median duration of first cry among the groups: water = 70.5 sec [interquartile range (IQR) = 5.5–104.5]; glucose = 2.0 sec (IQR = 0.0–45.0); milk = 29.5 sec (IQR = 0.0–65.0). Specifically, the duration of first cry was significantly shorter in the glucose group compared with the water group (Bonferroni adjustment, p = 0.011). Pain scores were significantly lower in the glucose and milk groups compared with the water group 1, 2 and 3 min after heel lancing (p < 0.05).
Although milk did not significantly reduce crying time, our finding that pain scores were significantly lower in the milk group suggests that milk may reduce pain associated with heel lancing in preterm neonates.