Usefulness of the delta neutrophil index for assessing neonatal sepsis
Article first published online: 7 NOV 2012
©2012 The Author(s)/Acta Pædiatrica ©2012 Foundation Acta Pædiatrica
Volume 102, Issue 1, pages e13–e16, January 2013
How to Cite
Lee, S. M., Eun, H. S., Namgung, R., Park, M. S., Park, K. I. and Lee, C. (2013), Usefulness of the delta neutrophil index for assessing neonatal sepsis. Acta Paediatrica, 102: e13–e16. doi: 10.1111/apa.12052
- Issue published online: 11 DEC 2012
- Article first published online: 7 NOV 2012
- Accepted manuscript online: 3 NOV 2012 12:07AM EST
- Manuscript Accepted: 4 OCT 2012
- Manuscript Revised: 13 SEP 2012
- Manuscript Received: 13 AUG 2012
- CRP ;
- Delta neutrophil index;
- Neonatal sepsis
We investigated the significance of the calculated delta neutrophil index (DNI) as a diagnostic factor for neonatal sepsis.
In retrospective study, 24 infants were diagnosed with blood culture-proven sepsis, and 48 non-septic neonates matched for gestational age, and birth weight served as controls. Among the 24 infants with sepsis, 5 died within 7 days at diagnosis.
Mean DNI (at diagnosis, after 24 h and 72 h), CRP and WBC counts were significantly higher, and neutrophil and platelet counts were significantly lower in sepsis group than control group. In sepsis group, mean DNI at the time of diagnosis, DNI at 72 h, and CRP at 72 h were significantly higher, and platelet counts were significantly lower for patients with sepsis who died compared with those who survived. In multiple logistic regression analysis, mortality in neonates with sepsis significantly correlated with DNI at 72 h (OR 1.47, 95% CI 1.1–5.6, p = 0.032) and with platelet count (OR 0.93, 95% CI 0.51–0.99, p = 0.014). ROC analysis for DNI at 72 h revealed a cut-off value of 12%, which predicted mortality with 81% sensitivity and 87% specificity.
DNI may be a valuable tool in assessing the prognosis of patients with neonatal sepsis.