Relationship of Δ6-desaturase and Δ5-desaturase activities with thyroid hormone status in adolescents with eating disorders and weight loss
Article first published online: 19 JAN 2013
©2013 The Author(s)/Acta Pædiatrica ©2013 Foundation Acta Pædiatrica
Volume 102, Issue 4, pages 416–418, April 2013
How to Cite
Swenne, I. and Vessby, B. (2013), Relationship of Δ6-desaturase and Δ5-desaturase activities with thyroid hormone status in adolescents with eating disorders and weight loss. Acta Paediatrica, 102: 416–418. doi: 10.1111/apa.12132
- Issue published online: 18 MAR 2013
- Article first published online: 19 JAN 2013
- Manuscript Accepted: 11 DEC 2012
- Manuscript Revised: 29 NOV 2012
- Manuscript Received: 27 SEP 2012
- Child Health Care, the Gillbergska Foundation
- Eating disorder;
- PUFA ;
In starvation, there is down-regulation of metabolism and changes in essential fatty acid (FA) status, which could be related to alterations of desaturase activities. Presently, the relationship between thyroid hormones and desaturase activities has been investigated in adolescents with eating disorders and weight loss.
Serum triiodothyronine concentrations and proportions of polyunsaturated FA in plasma phospholipids were analysed in blood samples from 227 adolescents with ED. Δ6-desaturase (D6D) activity was calculated as the FA ratio 20:3ω6/18:2ω6 and Δ5-desaturase (D5D) activity as the ratio 20:4ω6/20:3ω6.
Serum triiodothyronine concentrations were related to leanness and ongoing weight loss. The estimated D6D activity was positively correlated with serum triiodothyronine (R2 = 0.232; p < 0.001). D5D activity exhibited a strong inverse correlation with serum triiodothyronine (R2 = 0.410; p < 0.001).
Changes in desaturase activities during starvation cannot be explained by inhibition/disinhibition by essential FA only. It is possible that the effects of starvation on these enzyme activities, and hence on essential FA status, are mediated by triiodothyronine.