Foetal umbilical artery Doppler in small preterms: (IQ) Neurocognitive outcome at 5 years of age
Article first published online: 11 FEB 2013
©2013 The Author(s)/Acta Pædiatrica ©2013 Foundation Acta Pædiatrica
Volume 102, Issue 4, pages 403–409, April 2013
How to Cite
Eger, S. H. W., Sommerfelt, K., Kiserud, T. and Markestad, T. (2013), Foetal umbilical artery Doppler in small preterms: (IQ) Neurocognitive outcome at 5 years of age. Acta Paediatrica, 102: 403–409. doi: 10.1111/apa.12164
- Issue published online: 18 MAR 2013
- Article first published online: 11 FEB 2013
- Accepted manuscript online: 17 JAN 2013 09:57PM EST
- Manuscript Accepted: 11 JAN 2013
- Manuscript Revised: 1 JAN 2013
- Manuscript Received: 19 NOV 2012
- Norwegian Foundation for Health and Rehabilitation
- Unexpected Child Death Society of Norway
- Research Council of Norway
- Absent or reversed end-diastolic flow;
- Cognitive impairment;
- Extremely low birth weight;
- Extremely premature infant;
- Neonatal mortality and morbidity
To investigate whether absent or reversed end-diastolic flow in the umbilical artery (AREDF) is associated with neonatal mortality, morbidity or long-term neurocognitive outcome in extremely preterm infants exposed to preeclampsia or intrauterine growth restriction.
Prenatal Doppler data were retrospectively collected for liveborn infants with gestational age (GA) <28 weeks or birth weight (BW) <1000 g, born small for gestational age (SGA- BW <5th percentile for GA) or of mothers with preeclampsia at the four largest university hospitals in Norway during 1999–2000. Neonatal mortality and morbidities, cerebral palsy (CP) and IQ at 5 years of age were compared for infants with or without AREDF.
Of 260 infants, 84 were eligible and 71 of them had sufficient Doppler data. Of these, 38 (54%) had AREDF. Of 33 infants born <28 weeks, 7 of 19 (37%) with AREDF and none of 14 without AREDF had severe cerebral haemorrhage (SCH) (p = 0.01). AREDF was not significantly associated with mortality, other NICU morbidities, CP or reduced IQ. For the 38 infants with GA ≥28 weeks, AREDF (19 of 38) was not associated with adverse outcomes.
Absent or reversed end-diastolic flow in the umbilical artery (AREDF) was associated with increased risk of SCH in extremely preterm infants (GA <28 weeks).