Effects of delayed cord clamping on neurodevelopment and infection at four months of age: a randomised trial
Article first published online: 11 FEB 2013
©2013 The Author(s)/Acta Pædiatrica ©2013 Foundation Acta Pædiatrica
Volume 102, Issue 5, pages 525–531, May 2013
How to Cite
Andersson, O., Domellöf, M., Andersson, D. and Hellström-Westas, L. (2013), Effects of delayed cord clamping on neurodevelopment and infection at four months of age: a randomised trial. Acta Paediatrica, 102: 525–531. doi: 10.1111/apa.12168
- Issue published online: 9 APR 2013
- Article first published online: 11 FEB 2013
- Accepted manuscript online: 21 JAN 2013 08:54AM EST
- Manuscript Accepted: 14 JAN 2013
- Manuscript Revised: 20 NOV 2012
- Manuscript Received: 17 SEP 2012
- Umbilical cord clamping
To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life.
Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G was measured at birth, 2–3 days and 4 months. Parents recorded any symptoms indicating infection during the first 4 months of life.
The total scores from the ASQ did not differ between groups. However, the delayed cord clamping (DCC) group had a higher mean (SD) score in the problem-solving domain [55.3 (7.2) vs. 53.5 (8.2), p = 0.03] at 4 months and a lower mean (SD) score in the personal-social domain [49.5 (9.3) vs. 51.8 (8.1), p = 0.01]. The IgG level was higher in the DCC group at 2–3 days (11.7 vs. 11.0 g/L, p = 0.004), but did not differ between the groups at 4 months. Symptoms of infection were comparable between the groups.
Delayed cord clamping did not affect overall neurodevelopment or symptoms of infection up to 4 months of age, but may have an impact on specific neurodevelopmental domains.