Prevalence of congenital heart disease at live birth: an accurate assessment by echocardiographic screening
Article first published online: 11 FEB 2013
©2013 The Author(s)/Acta Pædiatrica ©2013 Foundation Acta Pædiatrica
Volume 102, Issue 4, pages 397–402, April 2013
How to Cite
Zhao, Q.-m., Ma, X.-j., Jia, B. and Huang, G.-y. (2013), Prevalence of congenital heart disease at live birth: an accurate assessment by echocardiographic screening. Acta Paediatrica, 102: 397–402. doi: 10.1111/apa.12170
- Issue published online: 18 MAR 2013
- Article first published online: 11 FEB 2013
- Accepted manuscript online: 25 JAN 2013 08:23AM EST
- Manuscript Accepted: 17 JAN 2013
- Manuscript Revised: 21 DEC 2012
- Manuscript Received: 30 NOV 2012
- Songjiang District Central Hospital
- Songjiang Maternity and Child Health Hospital
- Ministry of Health. Grant Number: 2010-239
- National Basic Research Project of China. Grant Number: 2010CB529504
- Congenital heart disease;
- Newborn screening;
To determine the true prevalence of congenital heart disease (CHD) at live birth using echocardiographic screening.
A total of 5190 consecutive newborns from two secondary hospitals were included. Each neonate had a complete clinical evaluation with echocardiographic diagnosis at average 47 h of age. Newborns with persistent CHD underwent at least 4 months of follow-up, and the temporal trend of prevalence of mild CHD was assessed.
Overall live birth prevalence of CHD was 26.6‰ (severe 3.5‰, moderate 5.4‰ and mild 17.7‰), and prevalence of CHD that could be detected by clinical evaluation was 12.1‰. The most common CHD was ventricular septal defect (VSD, 17.3‰), followed by atrial septal defect (ASD, 6.2‰), patent ductus arteriosus (PDA, 1.3‰), tetralogy of Fallot (TOF, 0.4‰), single ventricle (SV, 0.4‰), atrioventricular septal defect (AVSD, 0.2‰) and double outlet right ventricle (DORV, 0.2‰). Female predominance was observed in mild CHD (VSD, ASD), and male predominance was observed in severe CHD. The prevalence of CHD was reduced to 19.5‰ at the 4-month follow-up, which was largely caused by spontaneous closure rate of muscular VSD.
Prevalence of CHD determined by echocardiography screening was higher but more accurate than that obtained from birth defect registries.