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Uncoupling protein-2 gene polymorphisms are associated with obesity in Hungarian children



Katalin Csernus, Department of Pediatrics, University of Pécs, József A. u. 7., Pécs 7623, Hungary.

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To determine the frequency of common polymorphisms of genes associated with energy metabolism among normal weight and overweight/obese children to look for effects on childhood obesity.


Among 709 overweight/obese and 637 normal weight children (age 6–17 years), anthropometric measurements were carried out and genotyping for the following gene polymorphisms: β3-adrenoreceptor Trp64Arg, uncoupling protein (UCP) -1 –3826 A/G, UCP-2 –866 G/A and exon 8 del/ins, UCP-3 –55 C/T and peroxisome proliferator-activated receptor-γ Pro12Ala.


On multivariate regression analysis adjusted for age and gender heterozygosity and homozygosity for the UCP-2 –866 A variant was associated with an odds ratio (OR) for obesity of 0.69 (95% CI: 0.52–0.92; p = 0.013) and 0.50 (95% CI: 0.32–0.79; p = 0.003), respectively, compared with G/G homozygotes. Heterozygotes and homozygotes for the UCP-2 exon 8 ins allele had an OR for obesity of 1.66 (95% CI: 1.24–2.23; p = 0.001) and 2.12 (95% CI: 1.23–3.63; p = 0.006), respectively, compared with del/del homozygotes. There were no significant differences in obesity risk in association with the other examined gene polymorphisms.


Common polymorphisms of the UCP-2 gene might influence the propensity to overweight/obesity in Hungarian children.