Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth
Article first published online: 27 FEB 2013
©2013 The Author(s)/Acta Pædiatrica ©2013 Foundation Acta Pædiatrica
Volume 102, Issue 5, pages 480–485, May 2013
How to Cite
Keski-Nisula, L., Kyynäräinen, H.-R., Kärkkäinen, U., Karhukorpi, J., Heinonen, S. and Pekkanen, J. (2013), Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth. Acta Paediatrica, 102: 480–485. doi: 10.1111/apa.12186
- Issue published online: 9 APR 2013
- Article first published online: 27 FEB 2013
- Accepted manuscript online: 7 FEB 2013 06:49AM EST
- Manuscript Accepted: 1 FEB 2013
- Manuscript Revised: 21 JAN 2013
- Manuscript Received: 26 OCT 2012
- Kuopio University Hospital
To estimate the transmission of maternal vaginal microbiota to neonates during term delivery, focusing on Lactobacillus flora in relation to various obstetric clinical factors.
Fifty consecutive pregnant healthy women with singleton term pregnancies and their newborn infants. Vertical transmission of Lactobacillus flora to the newborn during delivery was evaluated in 45 mother–newborn pairs.
Lactobacillus-dominant mixed flora was detected in 90% (N = 45) of vaginal samples, but only in 28% (N = 14) of neonatal cultures (transmission rate 31%). All neonates with Lactobacillus-dominant mixed flora had findings similar to those in maternal cultures. Cocci-dominant flora was the most common finding in neonates. Administration of antibiotics to the mother during the intrapartum period before birth and duration of rupture of membranes (ROM), regardless of maternal antibiotic treatment, were associated significantly with a decreased transmission rate of Lactobacillus-dominant mixed flora to neonates.
Maternal intrapartum antibiotics and prolonged expectant management after ROM were associated with decreased transmission rate of vaginal Lactobacillus flora to the neonate during birth. As early colonization of Lactobacillus flora may have a preventive role in the development of allergic diseases later, the significance of intrapartum prophylactic antibiotics needs to be highlighted in forthcoming studies, especially as regards immunological development of the offspring.