Predictive value of neonatal brain MRI on the neurodevelopmental outcome of preterm infants by 5 years of age
Article first published online: 4 MAR 2013
©2013 The Author(s)/Acta Pædiatrica ©2013 Foundation Acta Pædiatrica
Volume 102, Issue 5, pages 492–497, May 2013
How to Cite
Setänen, S., Haataja, L., Parkkola, R., Lind, A., Lehtonen, L. (2013), Predictive value of neonatal brain MRI on the neurodevelopmental outcome of preterm infants by 5 years of age. Acta Paediatrica, 102: 492–497. doi: 10.1111/apa.12191
- Issue published online: 9 APR 2013
- Article first published online: 4 MAR 2013
- Accepted manuscript online: 7 FEB 2013 02:17PM EST
- Manuscript Accepted: 4 FEB 2013
- Manuscript Revised: 30 JAN 2013
- Manuscript Received: 12 DEC 2012
- Cognitive Development;
- CP ;
To study the prognostic value of MRI in preterm infants at term equivalent age for cognitive development at 5 years of age.
A total of 217 very low birth weight/very low gestational age infants who all received brain MRI at term equivalent age were categorized into 4 groups based on the brain MRI findings. Cognitive development was assessed at 5 years of chronological age by using a short form of Wechsler Preschool and Primary Scale of Intelligence – Revised. This information was combined with neurosensory diagnoses by 2 years of corrected age.
Of all infants 31 (17.0%) had Full Scale Intelligence Quotient (FSIQ) <85, 14 (6.5%) had cerebral palsy and 4 (1.8%) had severe hearing impairment. A total of 41 (22.0%) infants had some neurodevelopmental impairment at 5 years of age. Considering cognitive outcome (FSIQ <85), the positive predictive value of several major MRI pathologies was 43.8%, and the negative predictive value of normal finding or minor pathologies was 92.0% and 85.7%, respectively.
The MRI of the brain at term equivalent age may be valuable in predicting neurodevelopmental outcome in preterm infants by 5 years of age. The findings should always be interpreted alongside the clinical information of the infant. Furthermore, MRI should not replace a long-term clinical follow-up for very preterm infants.