Toll-like receptors in Neonatal Sepsis

Authors

  • Fiona M O’Hare,

    Corresponding author
    1. Department of Neonatology, National Maternity Hospital, Dublin, Ireland
    • Correspondence F O'Hare, BA, MB, Bch, BAO, MRCPI, Paediatric Specialist Registrar, National Maternity Hospital, Holles Street, Dublin 2, Ireland. Tel: +01-6373100 | Fax: +353 1 6614623 | Email: fionaohare@physicians.ie

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  • R William Watson,

    1. School of Medicine & Medical Science, University College Dublin, Dublin, Ireland
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  • Eleanor J Molloy

    1. Department of Neonatology, National Maternity Hospital, Dublin, Ireland
    2. School of Medicine & Medical Science, University College Dublin, Dublin, Ireland
    3. Department of Paediatrics, Royal College of Surgeons of Ireland, Dublin, Ireland
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Abstract

Toll-like receptors are vital transmembrane receptors that initiate the innate immune response to many micro-organisms. The discovery of these receptors has improved our understanding of host–pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.

Conclusion

Toll-like receptor modulation may potentially be used as immunomodulators in the management of neonatal sepsis.

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