Leptin and adiponectin in cord blood from children of normal weight, overweight and obese mothers
Article first published online: 6 MAR 2013
©2013 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd
Volume 102, Issue 6, pages 620–624, June 2013
How to Cite
Brynhildsen, J., Sydsjö, G., Blomberg, M., Claesson, I.-M., Theodorsson, E., Nyström, F., Sydsjö, A. and Josefsson, A. (2013), Leptin and adiponectin in cord blood from children of normal weight, overweight and obese mothers. Acta Paediatrica, 102: 620–624. doi: 10.1111/apa.12202
- Issue published online: 6 MAY 2013
- Article first published online: 6 MAR 2013
- Accepted manuscript online: 14 FEB 2013 12:27PM EST
- Manuscript Accepted: 12 FEB 2013
- Manuscript Revised: 8 FEB 2013
- Manuscript Received: 14 JAN 2013
- The Health Research Council of the Southeast of Sweden
- Umbilical cord
To study cord blood concentrations of adiponectin and leptin in children born by normal weight, overweight and obese mothers and to study these parameters in relation to a weight gain intervention programme for obese mothers.
Ten millilitre cord blood was collected and analysed for leptin and adiponectin concentrations in children with gestational age >37 weeks born by 60 normal weight, 45 overweight and 145 obese mothers. 82 obese mothers took part in a weight gain intervention programme.
Concentrations of leptin and adiponectin were higher in cord blood from children of overweight and obese mothers compared with children of normal weight mothers (leptin: Md 13.2, 30, 3 and 90.2 ng/mL respectively, p < 0.001; adiponectin 35.9, 205.4, 213.8 ng/L p < 0.001). No differences were found between overweight and obese mothers.
The weight gain intervention programme for obese pregnant women had significant effects on the weight gain during pregnancy but had no effects on cord blood serum concentrations of leptin and adiponectin.
Cord blood leptin and adiponectin concentrations were higher in children born by overweight or obese women compared with children of normal weight mothers. A weight gain intervention programme for obese pregnant women did not affect these results. Intrauterine exposition to high concentrations of leptin and adiponectin may play a role in weight development later in life.