Investigation of novel genes for lung function in children and their interaction with tobacco smoke exposure: a preliminary report
Article first published online: 6 MAR 2013
©2013 Foundation Acta Pædiatrica. Published by Blackwell Publishing Ltd
Volume 102, Issue 5, pages 498–503, May 2013
How to Cite
Panasevich, S., Melén, E., Hallberg, J., Bergström, A., Svartengren, M., Pershagen, G. and Nyberg, F. (2013), Investigation of novel genes for lung function in children and their interaction with tobacco smoke exposure: a preliminary report. Acta Paediatrica, 102: 498–503. doi: 10.1111/apa.12204
- Issue published online: 9 APR 2013
- Article first published online: 6 MAR 2013
- Accepted manuscript online: 14 FEB 2013 12:27PM EST
- Manuscript Accepted: 12 FEB 2013
- Manuscript Revised: 20 DEC 2012
- Manuscript Received: 10 MAY 2012
- Swedish Research Council
- Swedish Heart Lung Foundation
- strategic research programme in epidemiology
- Gene–environment interaction;
- Lung function;
- Tobacco smoke
To replicate newly reported single nucleotide polymorphism (SNP) associations with adult lung function in a cohort of children and to investigate interactions with tobacco smoke exposure on lung function.
Of 37 reported SNPs in adults, 21 were available in our genome-wide association study data set, either directly genotyped or as proxy SNPs. We tested for association with lung function (FEV1, FVC, FEV1/FVC%) in 8-year-old children and analysed interaction with tobacco smoke exposure both prenatally and/or during infancy, as well as at the age of 8 years.
SNPs in TNS1, ADAM19, THSD4 and ADCY2 showed significant association with lung function in children, although ADCY2 variants not in the expected direction. For example, variant allele A in THSD4 rs12899618 was associated with 50.2 mL higher FEV1 (p = 0.007) and variant allele C in ADAM19 rs2277027 with 1% unit lower FEV1/FVC% (p = 0.03) per allele. DAAM2 rs2395730 showed interaction with current tobacco smoke exposure, with variant C allele associated with 1.3% unit decrease in FEV1/FVC% in exposed children, but not in unexposed (p for interaction 0.04).
Our data replicate in children an association for TNS1, ADAM19, THSD4 and ADCY2 gene variants with lung function and suggest that interaction with tobacco smoke exposure may be of importance.