Get access

Does cow's milk protein elimination diet have a role on induction and maintenance of remission in children with ulcerative colitis?

Authors

  • Caterina Strisciuglio,

    1. Department of Translational Medical Science, Section of Pediatrics, University of Naples “Federico II”, Naples, Italy
    Search for more papers by this author
  • Eleonora Giannetti,

    1. Department of Translational Medical Science, Section of Pediatrics, University of Naples “Federico II”, Naples, Italy
    Search for more papers by this author
  • Massimo Martinelli,

    1. Department of Translational Medical Science, Section of Pediatrics, University of Naples “Federico II”, Naples, Italy
    Search for more papers by this author
  • Elisa Sciorio,

    1. Department of Translational Medical Science, Section of Pediatrics, University of Naples “Federico II”, Naples, Italy
    Search for more papers by this author
  • Annamaria Staiano,

    Corresponding author
    1. Department of Translational Medical Science, Section of Pediatrics, University of Naples “Federico II”, Naples, Italy
    • Correspondence

      Annamaria Staiano, Department of Translational Medical Science, Section of Pediatrics, University of Naples “Federico II”, Via S. Pansini, 5, 80131 Naples, Italy

      Tel: +39.081.7462679 |

      Fax: +39.081.5469811 |

      Email: staiano@unina.it

    Search for more papers by this author
  • Erasmo Miele

    1. Department of Translational Medical Science, Section of Pediatrics, University of Naples “Federico II”, Naples, Italy
    Search for more papers by this author

Abstract

Aim

Aims of this study were to evaluate the efficacy of a cow's milk protein (CMP) elimination diet on induction and maintenance of remission and to define association with atopy in children with ulcerative colitis (UC).

Methods

Twenty-nine consecutive patients (mean age: 11.2 years; range: 4.6–17 years; F/M: 15/14) with newly diagnosed UC were randomized either to receive a CMP elimination diet (n = 14) or to continue a free diet (n = 15) associated with concomitant steroid induction and mesalazine maintenance treatment. Children were prospectively evaluated at four time points: within 1 month, 6 months and 1 year after diagnosis or at the time of relapse.

Results

Twenty-five of the 29 enrolled patients responded to the UC induction therapy with a complete remission (86.2%), 13 belonging to CMP elimination diet group and 12 to free diet group (p = 0.59). Overall, our data showed that 7 of 13 (53.8%) patients treated with CMP elimination diet and 8 of 15 (53.3%) patients on free diet and UC therapy relapsed within 1 year of follow-up (p = 1).

Conclusions

In conclusion, data of this paediatric, randomized trial suggest that CMP elimination has no role in the management of UC in non-sensitized children.

Ancillary