Association between brain-derived neurothropic factor variants and asthma in Chinese Han children
Article first published online: 25 MAR 2013
©2013 Foundation Acta Pædiatrica. Published by Blackwell Publishing Ltd
Volume 102, Issue 6, pages e247–e250, June 2013
How to Cite
Yinli, C., Jie, H., Li, Z., Jun, G., Peiling, L. and Weihong, Y. (2013), Association between brain-derived neurothropic factor variants and asthma in Chinese Han children. Acta Paediatrica, 102: e247–e250. doi: 10.1111/apa.12224
- Issue published online: 6 MAY 2013
- Article first published online: 25 MAR 2013
- Accepted manuscript online: 5 MAR 2013 02:44PM EST
- Manuscript Accepted: 27 FEB 2013
- Manuscript Revised: 3 FEB 2013
- Manuscript Received: 9 JAN 2013
- Brain-derived neurotrophic factor;
- Childhood asthma;
- Genetic susceptibility;
- Single nucleotide polymorphisms
To identify the markers contributing to genetic susceptibility to asthma in Chinese Han children.
This study examined the potential association between childhood asthma and seven single nucleotide polymorphisms of Brain-derived Neurotrophic Factor (BDNF) – SNPs, rs16917204, rs6265, rs7103873, rs16917237, rs56164415, rs13306221 and rs10767664 – using the MassARRAY system. The participants, recruited between May 2009 and July 2012, were 319 children with asthma (mean age 9.82 ± 1.57 years) recruited from a hospital paediatric department and 309 healthy controls (mean age 10.25 ± 1.36 years), recruited from the medical examination centre at the same hospital.
We observed a significant association for rs6265 (χ2 = 9.851, p = 0.002, OR = 1.427, 95% CI = 1.143–1.783), located in exon 4 of the BDNF. Another potential association was observed for rs13306221 (χ2 = 4.316, p = 0.038, OR = 1.604, 95% CI = 1.024–2.512) in the promoter region of the BDNF. Strong linkage disequilibrium was observed in block 1 (D' > 0.9). Significantly more G-G-G haplotypes in block 1 were found in children with asthma.
These findings point to a role for BDNF polymorphisms in Chinese Han children with asthma and may inform future genetic or biological studies on childhood asthma.