Trial registration number: Ref No CTRI/2012/04/002570
Feasibility of exclusive enteral feeds from birth in VLBW infants >1200 g – an RCT
Article first published online: 29 APR 2013
©2013 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd
Volume 102, Issue 7, pages e299–e304, July 2013
How to Cite
Sanghvi, K. P., Joshi, P., Nabi, F. and Kabra, N. (2013), Feasibility of exclusive enteral feeds from birth in VLBW infants >1200 g – an RCT. Acta Paediatrica, 102: e299–e304. doi: 10.1111/apa.12254
- Issue published online: 30 MAY 2013
- Article first published online: 29 APR 2013
- Manuscript Accepted: 25 MAR 2013
- Manuscript Revised: 17 MAR 2013
- Manuscript Received: 8 JAN 2013
- Early enteral feeding;
- Enteral feeding;
- Exclusive enteral feeding;
- Preterm infants;
- VLBW infants
To evaluate the feasibility of initiation of exclusive enteral feeds on first day of life in very low birthweight infants >1200 g.
Haemodynamically stable infants with birthweights 1200–1500 g irrespective of gestational age were randomized into two groups. Study group: Enteral feeds 80 mL/kg/day started within 1 h of birth and increased by 20 mL/kg/day to 180 mL/kg/day. No intravenous fluids given. Control group: Intravenous fluids 50 mL/kg/day started along with enteral feeds 30 mL/kg/day within 1 h of birth and increased by 20 mL/kg/day to 180 mL/kg/day. The outcome measures were – primary: time to regain birthweight and secondary: duration of hospital stay, incidence of necrotizing enterocolitis and sepsis.
Twenty three babies randomized in each group. Infants in study group regained birthweight earlier [mean 5.52 days, SD ± 2.94] compared to those in control group [mean 12.7 days, SD ± 2.25] (p < 0.0001). Duration of hospital stay was lower in study group [mean 15.04 days, SD ± 5.26] compared to those in control group [mean 28.04 days, SD ± 6.76] (p < 0.0001). No necrotizing enterocolitis detected.
It is feasible to initiate exclusive enteral feeds from first day of life in stable infants with birthweight between 1200 and 1500 g without any parenteral fluid support. It leads to twice as faster regaining of birthweight and halves duration of hospital stay.