Can the retinal microvasculature offer clues to cardiovascular risk factors in early life?

Authors

  • Ling-Jun Li,

    1. Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore
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  • Yung-Seng Lee,

    1. Department of Paediatrics, National University of Singapore, Singapore, Singapore
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  • Tien-Yin Wong,

    1. Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore
    2. Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore
    3. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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  • Carol Yim-Lui Cheung

    Corresponding author
    1. Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore
    2. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    • Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore
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Correspondence

Dr. Carol Yim-Lui Cheung, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. 11 Third Hospital Avenue, Singapore 168751, Singapore.

Tel: (65) 6322 4543 |

Fax: (65) 6323 1903 |

Email: carol.cheung.y.l@seri.com.sg

Abstract

Adulthood cardiovascular diseases (CVD) burdening in adulthood have been suggested to have possible predisposition early in life. We aimed to systematically review the literatures on retinal microvasculature among paediatric population in relation to a range of environmental and systemic changes. Papers with quantitative retinal vascular assessment and epidemiological design were reviewed.

Conclusion

This review supports the theory that major vascular diseases have pathological predisposition early in life by providing morphological evidence on retinal microcirculation in vivo.

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